Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.
Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA 98195, USA.
Nutrients. 2022 Mar 25;14(7):1365. doi: 10.3390/nu14071365.
Vitamin A is vital to maternal-fetal health and pregnancy outcomes. However, little is known about pregnancy associated changes in maternal vitamin A homeostasis and concentrations of circulating retinol metabolites. The goal of this study was to characterize retinoid concentrations in healthy women ( = 23) during two stages of pregnancy (25-28 weeks gestation and 28-32 weeks gestation) as compared to ≥3 months postpartum. It was hypothesized that plasma retinol, retinol binding protein 4 (RBP4), transthyretin and albumin concentrations would decline during pregnancy and return to baseline by 3 months postpartum. At 25-28 weeks gestation, plasma retinol (-27%), 4-oxo-13--retinoic acid (-34%), and albumin (-22%) concentrations were significantly lower, and -retinoic acid (+48%) concentrations were significantly higher compared to ≥3 months postpartum in healthy women. In addition, at 28-32 weeks gestation, plasma retinol (-41%), retinol binding protein 4 (RBP4; -17%), transthyretin (TTR; -21%), albumin (-26%), 13--retinoic acid (-23%) and 4-oxo-13--retinoic acid (-48%) concentrations were significantly lower, whereas plasma -retinoic acid concentrations (+30%) were significantly higher than ≥3 months postpartum. Collectively, the data demonstrates that in healthy pregnancies, retinol plasma concentrations are lower, but -retinoic acid concentrations are higher than postpartum.
维生素 A 对母婴健康和妊娠结局至关重要。然而，人们对妊娠相关的母体维生素 A 动态平衡和循环视黄醇代谢物浓度变化知之甚少。本研究的目的是描述健康女性（n = 23）在妊娠两个阶段（妊娠 25-28 周和 28-32 周）与产后≥3 个月时的类视黄醇浓度特征。假设血浆视黄醇、视黄醇结合蛋白 4（RBP4）、转甲状腺素蛋白和白蛋白浓度在妊娠期间下降，并在产后 3 个月恢复到基线。在妊娠 25-28 周时，与产后≥3 个月相比，健康女性的血浆视黄醇（-27%）、4-氧-13--视黄酸（-34%）和白蛋白（-22%）浓度显著降低，而 -视黄酸（+48%）浓度显著升高。此外，在妊娠 28-32 周时，与产后≥3 个月相比，血浆视黄醇（-41%）、视黄醇结合蛋白 4（RBP4；-17%）、转甲状腺素蛋白（TTR；-21%）、白蛋白（-26%）、13--视黄酸（-23%）和 4-氧-13--视黄酸（-48%）浓度显著降低，而血浆 -视黄酸浓度（+30%）显著升高。总的来说，这些数据表明，在健康妊娠中，血浆视黄醇浓度较低，但 -视黄酸浓度较高。
