Gennaro Gisella, Cozzi Andrea, Schiaffino Simone, Sardanelli Francesco, Caumo Francesca
Unit of Breast Radiology, Veneto Institute of Oncology (IOV) IRCCS, Via Gattamelata 64, 35128 Padua, Italy.
Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Mangiagalli 31, 20133 Milano, Italy.
Cancers (Basel). 2022 Mar 31;14(7):1774. doi: 10.3390/cancers14071774.
The radiation dose associated with contrast-enhanced mammography (CEM) has been investigated only by single-center studies. In this retrospective study, we aimed to compare the radiation dose between two centers performing CEM within two prospective studies, using the same type of equipment. The CEM mean glandular dose (MGD) was computed for low energy (LE) and high energy (HE) images and their sum was calculated for each view. MGD and related parameters (entrance dose, breast thickness, compression, and density) were compared between the two centers using the Mann−Whitney test. Finally, per-patient MGD was calculated by pooling the two datasets and determining the contribution of LE and HE images. A total of 348 CEM examinations were analyzed (228 from Center 1 and 120 from Center 2). The median total MGD per view was 2.33 mGy (interquartile range 2.19−2.51 mGy) at Center 1 and 2.46 mGy (interquartile range 2.32−2.70 mGy) at Center 2, with a 0.15 mGy median difference (p < 0.001) equal to 6.2%. LE-images contributed between 64% and 77% to the total patient dose in CEM, with the remaining 23−36% being associated with HE images. The mean radiation dose for a two-view bilateral CEM exam was 4.90 mGy, about 30% higher than for digital mammography.
与对比增强乳腺摄影（CEM）相关的辐射剂量仅通过单中心研究进行过调查。在这项回顾性研究中，我们旨在比较在两项前瞻性研究中使用相同类型设备进行CEM检查的两个中心之间的辐射剂量。计算了低能量（LE）和高能量（HE）图像的CEM平均腺体剂量（MGD），并计算了每个视图的总和。使用Mann-Whitney检验比较了两个中心之间的MGD和相关参数（入射剂量、乳房厚度、压迫和密度）。最后，通过合并两个数据集并确定LE和HE图像的贡献来计算每位患者的MGD。共分析了348例CEM检查（中心1为228例，中心2为120例）。中心1每个视图的总MGD中位数为2.33 mGy（四分位间距2.19 - 2.51 mGy），中心2为2.46 mGy（四分位间距2.32 - 2.70 mGy），中位数差异为0.15 mGy（p < 0.001），相当于6.2%。在CEM中，LE图像对患者总剂量的贡献为64%至77%，其余23% - 36%与HE图像相关。双侧CEM两视图检查的平均辐射剂量为4.90 mGy，比数字乳腺摄影高约30%。
