INSERM UMR 1231 LNC, LabEX LipSTIC, Faculty of Medicine and Pharmacy, University of Bourgogne-Franche Comté, 21000 Dijon, France.
Reference Center for Rare Lung Diseases, University Hospital Dijon-Bourgogne, 21000 Dijon, France.
Cells. 2022 Apr 3;11(7):1209. doi: 10.3390/cells11071209.
Lipids are major actors and regulators of physiological processes within the lung. Initial research has described their critical role in tissue homeostasis and in orchestrating cellular communication to allow respiration. Over the past decades, a growing body of research has also emphasized how lipids and their metabolism may be altered, contributing to the development and progression of chronic lung diseases such as pulmonary fibrosis. In this review, we first describe the current working model of the mechanisms of lung fibrogenesis before introducing lipids and their cellular metabolism. We then summarize the evidence of altered lipid homeostasis during pulmonary fibrosis, focusing on their extracellular forms. Finally, we highlight how lipid targeting may open avenues to develop therapeutic options for patients with lung fibrosis.
脂质是肺部生理过程中的主要参与者和调节者。初步研究描述了它们在组织稳态和协调细胞通讯以实现呼吸中的关键作用。在过去的几十年中，越来越多的研究还强调了脂质及其代谢如何发生改变，从而导致慢性肺部疾病（如肺纤维化）的发展和进展。在本综述中，我们首先描述了肺纤维化发生机制的当前工作模型，然后介绍了脂质及其细胞代谢。接着，我们总结了肺纤维化过程中脂质动态平衡改变的证据，重点关注其细胞外形式。最后，我们强调了靶向脂质可能为肺纤维化患者开发治疗选择开辟途径。
