Li Xiaofang, Chen Haoze, Jia Yan, Peng Jinming, Li Chunmei
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Beijing Key Lab of Plant Resource Research and Development, School of Science, Beijing Technology and Business University, Beijing 100048, China.
Foods. 2022 Mar 29;11(7):1001. doi: 10.3390/foods11071001.
The pericarp of mangosteen, a by-product of the mangosteen, is rich in polyphenols. In this study, an efficient and environmentally friendly method for preparative enrichment of polyphenols from mangosteen pericarp (MPPs) was developed, and the inhibitory effects on starch digestion were also evaluated. It was found that the optimal extract method of MPPs was at a solid to solvent ratio of 1:50 g/mL, pH of 2, and at 80 °C for 2 h. The IC of MPPs for α-amylase was 0.28 mg/mL. Based on the fluorescence quenching results, we presumed that MPPs could alter the natural structure of α-amylase, resulting in inhibitory activity on α-amylase. In addition, MPPs significantly reduced the blood glucose peak and AUC of glucose responses in rats after ingestion of the starch solution. Taken together, MPPs may have the potential as a functional supplement for blood glucose control and diabetes prevention.
山竹果皮是山竹的一种副产品，富含多酚。在本研究中，开发了一种高效且环保的从山竹果皮中制备富集多酚的方法（MPPs），并评估了其对淀粉消化的抑制作用。结果发现，MPPs的最佳提取方法是固液比为1:50 g/mL、pH为2、在80℃下提取2小时。MPPs对α-淀粉酶的IC为0.28 mg/mL。基于荧光猝灭结果，我们推测MPPs可能会改变α-淀粉酶的天然结构，从而产生对α-淀粉酶的抑制活性。此外，MPPs显著降低了大鼠摄入淀粉溶液后的血糖峰值和葡萄糖反应的AUC。综上所述，MPPs可能具有作为血糖控制和糖尿病预防功能性补充剂的潜力。
