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多酚作为益生元在高脂饮食诱导肥胖管理中的应用：动物研究的系统评价

Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies.

作者信息

Moorthy Mohanambal, Sundralingam Usha, Palanisamy Uma D

机构信息

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.

Tropical Medicine and Biology Platform, School of Science, Monash University, Bandar Sunway 47500, Selangor, Malaysia.

出版信息

Foods. 2021 Feb 2;10(2):299. doi: 10.3390/foods10020299.

DOI:10.3390/foods10020299
PMID:33540692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7913110/
Abstract

Obesity is a disease growing at an alarming rate and numerous preclinical studies have proven the role of polyphenols in managing this disease. This systematic review explores the prebiotic effect of polyphenols in the management of obesity among animals fed on a high-fat diet. A literature search was carried out in PubMed, Scopus, CINAHL, Web of Science, and Embase databases following the PRISMA guidelines. Forty-four studies reported a significant reduction in obesity-related parameters. Most notably, 83% of the studies showed a decrease in either body weight/visceral adiposity/plasma triacylglyceride. Furthermore, 42 studies reported a significant improvement in gut microbiota (GM), significantly affecting the genera , , , , , , , and . Polyphenols' anti-obesity, anti-hyperglycaemic, and anti-inflammatory properties were associated with their ability to modulate GM. This review supports the notion of polyphenols as effective prebiotics in ameliorating HFD-induced metabolic derangements in animal models.

摘要

肥胖是一种正以惊人速度增长的疾病，众多临床前研究已证实多酚类物质在控制该疾病方面的作用。本系统综述探讨了多酚类物质在以高脂饮食喂养的动物中对肥胖管理的益生元效应。按照PRISMA指南，在PubMed、Scopus、CINAHL、Web of Science和Embase数据库中进行了文献检索。44项研究报告称肥胖相关参数显著降低。最值得注意的是，83%的研究显示体重/内脏脂肪/血浆甘油三酯有所下降。此外，42项研究报告称肠道微生物群（GM）有显著改善，对属、、、、、、、和产生了显著影响。多酚类物质抗肥胖、抗高血糖和抗炎的特性与其调节GM的能力有关。本综述支持多酚类物质作为有效益生元改善动物模型中高脂饮食诱导的代谢紊乱这一观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b69/7913110/b93b037ce27e/foods-10-00299-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b69/7913110/3da8a41c56e3/foods-10-00299-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b69/7913110/578803268856/foods-10-00299-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b69/7913110/3c2ee7dc2734/foods-10-00299-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b69/7913110/b93b037ce27e/foods-10-00299-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b69/7913110/3da8a41c56e3/foods-10-00299-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b69/7913110/578803268856/foods-10-00299-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b69/7913110/3c2ee7dc2734/foods-10-00299-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b69/7913110/b93b037ce27e/foods-10-00299-g004a.jpg

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