Kihal Nadjib, Nazemi Ali, Bourgault Steve
Department of Chemistry, Université du Québec, Montreal, QC H2X 2J6, Canada.
Quebec Network for Research on Protein Function, Engineering and Applications, PROTEO, Quebec City, QC G1V 0A6, Canada.
Nanomaterials (Basel). 2022 Apr 5;12(7):1223. doi: 10.3390/nano12071223.
Self-assembling π-conjugated systems constitute efficient building blocks for the construction of supramolecular structures with tailored functional properties. In this context, perylene diimide (PDI) has attracted attention owing to its chemical robustness, thermal and photo-stability, and outstanding optical and electronic properties. Recently, the conjugation of PDI derivatives to biological molecules, including oligonucleotides and peptides, has opened new avenues for the design of nanoassemblies with unique structures and functionalities. In the present review, we offer a comprehensive summary of supramolecular bio-assemblies based on PDI. After briefly presenting the physicochemical, structural, and optical properties of PDI derivatives, we discuss the synthesis, self-assembly, and applications of PDI bioconjugates.
自组装π共轭体系是构建具有定制功能特性的超分子结构的有效基石。在此背景下，苝二酰亚胺（PDI）因其化学稳定性、热稳定性和光稳定性以及出色的光学和电子特性而备受关注。最近，将PDI衍生物与包括寡核苷酸和肽在内的生物分子共轭，为设计具有独特结构和功能的纳米组装体开辟了新途径。在本综述中，我们全面总结了基于PDI的超分子生物组装体。在简要介绍PDI衍生物的物理化学、结构和光学性质后，我们讨论了PDI生物共轭物的合成、自组装及应用。
