Kim Min-Kyung
Department of Pathology, College of Medicine, Dongguk University, Gyeongju 38066, Korea.
J Clin Med. 2022 Mar 23;11(7):1773. doi: 10.3390/jcm11071773.
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Much progress has been made regarding the understanding of hepatocarcinogenesis, yet the long-term survival rate of HCC patients remains poor. Recent efforts have shown parafibromin has a pathologic role in many human cancers, but little is known about the effects of parafibromin in HCC. This study aimed to investigate the pattern of parafibromin expression and its clinicopathologic significance in human HCC. Immunohistochemical analysis of HCC and matched non-tumor liver tissues from 50 HCC patients showed that the nuclear expression of parafibromin was higher in HCC tissues (50/50 cases) than in non-tumor liver tissues (17/50 cases). Moreover, elevated parafibromin expression was found to be significantly correlated with the presence of microvascular invasion ( = 0.017), hepatitis virus infection-induced occurrence ( = 0.005), and poorer tumor differentiation (Edmondson-Steiner grade; = 0.000). Kaplan-Meier analysis showed that HCC patients with elevated parafibromin expression had poorer recurrence-free ( = 0.014, log-rank test = 6.079) and overall survival ( = 0.036, log-rank test = 4.414). These findings indicate parafibromin may be related to the pathogenesis of HCC and a potential prognostic marker for HCC patients after hepatectomy.
肝细胞癌（HCC）是全球癌症相关死亡的第二大主要原因。在肝癌发生的认识方面已取得了很大进展，但HCC患者的长期生存率仍然很低。最近的研究表明，副纤维蛋白在许多人类癌症中具有病理作用，但关于副纤维蛋白在HCC中的作用知之甚少。本研究旨在探讨副纤维蛋白在人类HCC中的表达模式及其临床病理意义。对50例HCC患者的HCC组织和配对的非肿瘤肝组织进行免疫组织化学分析，结果显示，副纤维蛋白的核表达在HCC组织（50/50例）中高于非肿瘤肝组织（17/50例）。此外，发现副纤维蛋白表达升高与微血管侵犯的存在（P = 0.017）、肝炎病毒感染诱发情况（P = 0.005）以及较差的肿瘤分化（Edmondson-Steiner分级；P = 0.000）显著相关。Kaplan-Meier分析表明，副纤维蛋白表达升高的HCC患者无复发生存率较差（P = 0.014，对数秩检验 = 6.079）和总生存率较差（P = 0.036，对数秩检验 = 4.414）。这些发现表明，副纤维蛋白可能与HCC的发病机制有关，并且是肝切除术后HCC患者的潜在预后标志物。
