Díaz Pollán Beatriz, Guedez López Gladys Virginia, García Clemente Paloma María, Jiménez González María, García Bujalance Silvia, Gómez-Gil Mirá María Rosa
Infectious Disease Unit, Internal Medicine Service, La Paz University Hospital, 28046 Madrid, Spain.
Clinical Microbiological Service, La Paz University Hospital, 28046 Madrid, Spain.
J Clin Med. 2022 Mar 25;11(7):1815. doi: 10.3390/jcm11071815.
The SARS-CoV-2 pandemic might have increased the risks of healthcare-associated infections (HAIs); however, several studies of HAI such as urinary tract infections (UTIs) and catheter-associated urinary tract infections (CAUTIs) have shown contradictory results. The aim of this study is to assess the clinical features of UTIs and bacterial isolates from urine samples of hospitalized COVID-19 patients. We conducted a retrospective observational study including 87 COVID-19 patients with UTIs admitted to our centre. Bacterial UTIs presented were 87: 9 (10.3%) community-acquired UTIs (coinfection group) and 78 (89.6%) hospital-acquired UTIs (superinfection group). In the coinfection group, the most frequent type was non-CAUTI with 5 (55.5%) patients; however, the most frequent UTI in the superinfection group was CAUTI, with 53 (67.9%) patients. The median number of days of hospitalization in coinfected patients was lower than superinfection patients: 13 (IQR 11, 23) vs. 34 days (IQR 23, 47) p < 0.006. All UTI patients admitted to ICU, 38 (43.7%), belonged to the superinfection group. The mortality rate was 26.4% (23/87), 22/23 in the superinfection group. The most common microorganisms were E. coli 27 (28.4%), E. faecalis 25 (26.3%) and E. faecium 20 (21.1%). There was an increased incidence of E. faecalis and E. faecium in UTIs as well as hospital-acquired UTIs. This can be related to urethral catheterization during hospitalization, UCI admissions and the number of days of hospitalization.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行可能增加了医疗保健相关感染（HAIs）的风险；然而，几项关于HAIs的研究，如尿路感染（UTIs）和导尿管相关尿路感染（CAUTIs），结果相互矛盾。本研究的目的是评估住院COVID-19患者尿液样本中UTIs的临床特征和细菌分离株。我们进行了一项回顾性观察研究，纳入了87例入住我们中心的COVID-19合并UTIs患者。出现的细菌性UTIs有87例：9例（10.3%）社区获得性UTIs（合并感染组）和78例（89.6%）医院获得性UTIs（重叠感染组）。在合并感染组中，最常见的类型是非CAUTI，有5例（55.5%）患者；然而，重叠感染组中最常见的UTI是CAUTI，有53例（67.9%）患者。合并感染患者的住院天数中位数低于重叠感染患者：13天（四分位间距11，23）对34天（四分位间距23，47），p<0.006。所有入住ICU的UTI患者中，38例（43.7%）属于重叠感染组。死亡率为26.4%（23/87），重叠感染组为22/23。最常见的微生物是大肠杆菌27例（28.4%）、粪肠球菌25例（26.3%）和屎肠球菌20例（21.1%）。UTIs以及医院获得性UTIs中粪肠球菌和屎肠球菌的发病率增加。这可能与住院期间的尿道插管、UCI入院情况和住院天数有关。
