College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea.
Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA.
Molecules. 2022 Mar 23;27(7):2075. doi: 10.3390/molecules27072075.
Described in this paper are studies on the preparation of three classes of dimethylpyridinols derived from pyridoxine fused with aminooxazole, aminoimidazole, and aminopyrrole. The key feature of this synthetic strategy is the manipulation of hydroxymethyl moiety of C(5)-position of the pyridoxine starting material along with the installation of an amino group at C(6)-position. Efficient and practical synthesis for the oxazole- and imidazole-fused targets was accomplished, while the instability of the pyrrole-fused one was observed.
本文介绍了三种二甲吡啶醇类化合物的制备研究，这些化合物是由吡哆醇与氨基噁唑、氨基咪唑和氨基吡咯缩合得到的。该合成策略的关键特点是对吡哆醇原料 C(5)位的羟甲基进行操作，并在 C(6)位上引入氨基。成功实现了噁唑和咪唑缩合目标物的高效、实用合成，而吡咯缩合产物则由于其不稳定性而无法获得。
