Department of Chemistry, School of Science, Tianjin University, Tianjin 300350, China.
Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, China.
Molecules. 2022 Mar 24;27(7):2088. doi: 10.3390/molecules27072088.
The efficient capture of multi-pollutant residues in food is vital for food safety monitoring. In this study, in-situ-fabricated magnetic MIL-53(Al) metal organic frameworks (MOFs), with good magnetic responsiveness, were synthesized and applied for the magnetic solid-phase extraction (MSPE) of chloramphenicol, bisphenol A, estradiol, and diethylstilbestrol. Terephthalic acid (HBDC) organic ligands were pre-coupled on the surface of amino-FeO composites (HBDC@FeO). FeO@MIL-53(Al) MOF was fabricated by in-situ hydrothermal polymerization of HBDC, Al (NO), and HBDC@FeO. This approach highly increased the stability of the material. The magnetic FeO@MIL-53(Al) MOF-based MSPE was combined with high-performance liquid chromatography-photo diode array detection, to establish a novel sensitive method for analyzing multi-pollutant residues in milk. This method showed good linear correlations, in the range of 0.05-5.00 μg/mL, with good reproducibility. The limit of detection was 0.004-0.108 μg/mL. The presented method was verified using a milk sample, spiked with four pollutants, which enabled high-throughput detection and the accuracies of 88.17-107.58% confirmed its applicability, in real sample analysis.
高效捕获食品中的多污染物残留对于食品安全监测至关重要。在本研究中，原位合成了具有良好磁响应性的磁性 MIL-53(Al) 金属有机骨架（MOFs），并将其应用于氯霉素、双酚 A、雌二醇和己烯雌酚的磁性固相萃取（MSPE）。对氨基 -FeO 复合材料（HBDC@FeO）表面进行预偶联，将对苯二甲酸（HBDC）有机配体接枝在表面上。通过原位水热聚合 HBDC、Al（NO ）和 HBDC@FeO 制备 FeO@MIL-53(Al) MOF。这种方法极大地提高了材料的稳定性。磁性 FeO@MIL-53(Al) MOF 基 MSPE 与高效液相色谱-光电二极管阵列检测相结合，建立了一种用于分析牛奶中多污染物残留的新型灵敏方法。该方法在 0.05-5.00 μg/mL 范围内表现出良好的线性相关性，具有良好的重现性。检测限为 0.004-0.108 μg/mL。该方法通过添加四种污染物的牛奶样品进行验证，实现了高通量检测，88.17-107.58%的准确度验证了其在实际样品分析中的适用性。
