Chang Jia, Zhou Jianhua, Gao Mingyang, Zhang Hongyan, Wang Tian
Shandong Provincial Key Laboratory of Animal Resistance Biology, Key Laboratory of Food Nutrition and Safety, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Foods. 2022 Oct 1;11(19):3057. doi: 10.3390/foods11193057.
Milk and dairy products are sources of exposure to estrogenic endocrine disrupting compounds (e-EDCs). Estrogenic disruptors can accumulate in organisms through the food chain and may negatively affect ecosystems and organisms even at low concentrations. Therefore, the analysis of e-EDCs in dairy products is of practical significance. Continuous efforts have been made to establish effective methods to detect e-EDCs, using convenient sample pretreatments and simple steps. This review aims to summarize the recently reported pretreatment methods for estrogenic disruptors, such as solid-phase extraction (SPE) and liquid phase microextraction (LPME), determination methods including gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), Raman spectroscopy, and biosensors, to provide a reliable theoretical basis and operational method for e-EDC analysis in the future.
牛奶和乳制品是接触雌激素类内分泌干扰化合物（e-EDCs）的来源。雌激素干扰物可通过食物链在生物体内蓄积，即使在低浓度下也可能对生态系统和生物体产生负面影响。因此，分析乳制品中的e-EDCs具有实际意义。人们一直在不断努力，通过便捷的样品前处理和简单的步骤来建立检测e-EDCs的有效方法。本综述旨在总结最近报道的雌激素干扰物预处理方法，如固相萃取（SPE）和液相微萃取（LPME），以及包括气相色谱-质谱联用（GC-MS）、液相色谱-质谱联用（LC-MS）、拉曼光谱和生物传感器在内的测定方法，为未来e-EDC分析提供可靠的理论基础和操作方法。
