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聚多巴胺涂层聚乳酸气凝胶作为组织工程应用的支架。

Polydopamine-Coated Poly-Lactic Acid Aerogels as Scaffolds for Tissue Engineering Applications.

机构信息

Department of Chemistry and Biology, INSTM Research Unit, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, SA, Italy.

Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, P.le Fermi, 80055 Portici, NA, Italy.

出版信息

Molecules. 2022 Mar 25;27(7):2137. doi: 10.3390/molecules27072137.

DOI:10.3390/molecules27072137
PMID:35408538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9000627/
Abstract

Poly-L-lactic acid (PLLA) aerogel-based scaffolds were obtained from physical PLLA gels containing cyclopentanone (CPO) or methyl benzoate (BzOMe) molecules. An innovative single step method of solvent extraction, using supercritical CO, was used to achieve cylindrical monolithic aerogels. The pore distribution and size, analyzed by SEM microscopy, were found to be related to the crystalline forms present in the physical nodes that hold the gels together, the stable α'-form and the metastable co-crystalline ε-form, detected in the PLLA/BzOMe and PLLA/CPO aerogels, respectively. A higher mechanical compressive strength was found for the PLLA/CPO aerogels, which exhibit a more homogenous porosity. In vitro biocompatibility tests also indicated that monolithic PLLA/CPO aerogels exhibited greater cell viability than PLLA/BzOMe aerogels. An improved biocompatibility of PLLA/CPO monolithic aerogels was finally observed by coating the surface of the aerogels with polydopamine (PDA) obtained by the in situ polymerization of dopamine (DA). The synergistic effect of biodegradable polyester (PLLA) and the biomimetic interface (PDA) makes this new 3D porous scaffold, with porosity and mechanical properties that are tunable based on the solvent used in the preparation process, attractive for tissue engineering applications.

摘要

聚左旋乳酸（PLLA）气凝胶基支架是由含有环戊酮（CPO）或苯甲酸甲酯（BzOMe）分子的物理 PLLA 凝胶获得的。采用超临界 CO2 的创新一步溶剂萃取法，可获得圆柱形整体气凝胶。通过扫描电子显微镜分析发现，孔径分布和尺寸与物理节点中存在的结晶形式有关，这些物理节点将凝胶固定在一起，分别在 PLLA/BzOMe 和 PLLA/CPO 气凝胶中检测到稳定的 α'-形式和亚稳共晶 ε-形式。PLLA/CPO 气凝胶的机械压缩强度更高，表现出更均匀的孔隙率。体外生物相容性测试还表明，整体 PLLA/CPO 气凝胶比 PLLA/BzOMe 气凝胶具有更高的细胞活力。最后，通过多巴胺（DA）原位聚合获得聚多巴胺（PDA）对气凝胶表面进行涂层处理，观察到 PLLA/CPO 整体气凝胶具有更好的生物相容性。可生物降解聚酯（PLLA）和仿生界面（PDA）的协同作用使这种具有可调孔隙率和机械性能的新型 3D 多孔支架在组织工程应用中具有吸引力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/81a99c668d23/molecules-27-02137-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/23a31c5d4101/molecules-27-02137-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/8d4c51999166/molecules-27-02137-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/417f8850e2c8/molecules-27-02137-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/cea494214e8f/molecules-27-02137-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/5d6a132e5e12/molecules-27-02137-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/bf2e697bcabd/molecules-27-02137-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/b50f01874de1/molecules-27-02137-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/f45626bb5a50/molecules-27-02137-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/81a99c668d23/molecules-27-02137-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/23a31c5d4101/molecules-27-02137-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/8d4c51999166/molecules-27-02137-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/417f8850e2c8/molecules-27-02137-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/cea494214e8f/molecules-27-02137-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/5d6a132e5e12/molecules-27-02137-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/bf2e697bcabd/molecules-27-02137-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/b50f01874de1/molecules-27-02137-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/f45626bb5a50/molecules-27-02137-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cd/9000627/81a99c668d23/molecules-27-02137-g009.jpg

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