Department of Chemistry, Soongsil University, 369 Sangdo-ro, Seoul 06978, Korea.
Integrative Institute of Basic Science, Soongsil University, 369 Sangdo-ro, Seoul 06978, Korea.
Molecules. 2022 Mar 27;27(7):2171. doi: 10.3390/molecules27072171.
Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content screening (HCS) has emerged as a powerful tool in the development of novel therapeutic agents. Herein, we review the recent advances in divergent synthetic approaches such as complexity-to-diversity (Ctd) and biomimetic strategies for the generation of structurally complex and diverse indole-based natural product and natural product-like small-molecule libraries.
考虑到具有高度复杂和多样结构的天然产物和类似天然产物的化合物的潜在生物活性，高通量筛选 (HTS) 和高内涵筛选 (HCS) 对天然产物和类似天然产物的化合物库和小分子库进行筛选已经成为开发新型治疗剂的有力工具。在此，我们综述了用于生成结构复杂多样的吲哚类天然产物和类似天然产物的小分子文库的复杂性-多样性 (Ctd) 和仿生策略等发散合成方法的最新进展。
