通过阿片碱的环扭曲获得结构复杂的化合物库。
Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine.
机构信息
Roger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
出版信息
Org Lett. 2016 Oct 7;18(19):4852-4855. doi: 10.1021/acs.orglett.6b02333. Epub 2016 Sep 21.
Abstract
Many compound collections used in high-throughput screening are composed of members whose structural complexity is considerably lower than that of natural products. We previously reported a strategy for the synthesis of complex and diverse small molecules from natural products using ring-distortion reactions, called complexity-to-diversity (CtD), and herein, CtD is applied in the synthesis of 16 diverse scaffolds and 65 total compounds from the alkaloid natural product sinomenine. Chemoinformatic analysis shows that these compounds possess complex ring systems and marked three-dimensionality.
摘要
许多用于高通量筛选的化合物库由其结构复杂性明显低于天然产物的成员组成。我们之前报道了一种使用环扭曲反应（称为复杂性到多样性，CtD）从天然产物中合成复杂多样的小分子的策略，在此，CtD 被应用于从生物碱天然产物青藤碱中合成 16 种不同骨架和 65 种总化合物。化学信息学分析表明，这些化合物具有复杂的环系统和显著的三维结构。
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