Department of Biochemistry, Ivan Franko National University of Lviv, 4 Hrushevskyi St., 79005 Lviv, Ukraine.
Department of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, C. K. Norwida 25, 50-375 Wrocław, Poland.
Molecules. 2022 Mar 30;27(7):2244. doi: 10.3390/molecules27072244.
Although extracts are broadly used in order to support the treatment of numerous diseases, only in a limited number of cases is the process of applying and establishing their mechanisms of action scientifically analyzed. Fruits of Cornelian cherry are an abundant source of iridoids, anthocyanins, flavonols and phenolic acids. The aim of the present study was to evaluate the in vitro bioactivity of red and yellow Cornelian cherry fruits' extracts. The biological potential of extracts, in a broad sense, involved antioxidant activity in relation to phosphatidylcholine liposomes, inhibitory ability against α-glucosidase and acetylcholinesterase enzymes, as well as interactions with human serum albumin. Studies showed that both extracts were more effective in protecting liposome membranes against free radicals produced by AAPH in an aqueous environment due to the fact that they can be better eliminated by the hydrophilic components of the extracts than those produced by UVB radiation. Extracts exhibited inhibitory activity against acetylcholinesterase and α-glucosidase, wherein loganic acid extract showed noncompetitive inhibition of the enzyme. Moreover, extracts binded to albumin mainly through hydrogen bonds and van der Waals forces. Taken together, red and yellow cherry fruits' extracts exhibit diverse biological properties and can be exploited as a source of natural therapeutic agents.
虽然提取物被广泛用于支持治疗许多疾病，但只有在有限的情况下，应用和建立其作用机制的过程才会被科学地分析。Cornelian 樱桃的果实是环烯醚萜类、花青素、黄酮醇和酚酸的丰富来源。本研究的目的是评估红色和黄色 Cornelian 樱桃果实提取物的体外生物活性。提取物的生物潜力，广义上涉及与磷脂酰胆碱脂质体的抗氧化活性、对α-葡萄糖苷酶和乙酰胆碱酯酶的抑制能力以及与人体血清白蛋白的相互作用。研究表明，由于它们可以通过提取物的亲水性成分更好地清除，而不是通过 UVB 辐射产生的自由基，两种提取物在保护脂质体膜免受 AAPH 在水相环境中产生的自由基方面更有效。提取物对乙酰胆碱酯酶和α-葡萄糖苷酶均表现出抑制活性，其中 loganic 酸提取物对酶表现出非竞争性抑制。此外，提取物主要通过氢键和范德华力与白蛋白结合。综上所述，红色和黄色樱桃果实的提取物表现出多种生物特性，可作为天然治疗剂的来源。
