Eye Center, Humanitas Gavazzeni-Castelli, 24128 Bergamo, Italy.
Department of Biomedical Sciences, Humanitas University, 20100 Milano, Italy.
Int J Mol Sci. 2022 Mar 24;23(7):3557. doi: 10.3390/ijms23073557.
Recent evidence in basic science is leading to a growing interest in the possible role of curcumin in treating retinal diseases. Curcumin has been demonstrated to be able to modulate gene transcription and reduce ganglion cell apoptosis, downgrade VEGF, modulate glucose levels and decrease vascular dysfunction. So far, the use of curcumin has been limited by poor bioavailability; to overcome this issue, different types of carriers have been used. Multiple recent studies disclosed the efficacy of using curcumin in treating different retinal conditions. The aim of this review is to comprehensively review and discuss the role of curcumin in retinal diseases from bench to bedside.
最近的基础科学研究证据表明，姜黄素在治疗视网膜疾病方面可能具有一定作用，引起了人们越来越多的关注。研究表明，姜黄素能够调节基因转录，减少神经节细胞凋亡，降低 VEGF 水平，调节血糖水平并减少血管功能障碍。迄今为止，姜黄素的应用受到生物利用度差的限制；为了解决这个问题，已经使用了不同类型的载体。最近的多项研究揭示了姜黄素在治疗不同视网膜疾病中的功效。本综述的目的是从基础到临床全面综述和讨论姜黄素在视网膜疾病中的作用。
