Luo Qiaoqiao, Shi Ruoyu, Liu Yutong, Huang Libo, Chen Wei, Wang Chengtao
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
College of Animal Science and Technology, Shandong Agricultural University, Taian 271000, China.
Int J Mol Sci. 2022 Mar 28;23(7):3710. doi: 10.3390/ijms23073710.
Huangjiu usually caused rapid-drunkenness and components such as β-benzyl ethanol (β-be), isopentanol (Iso), histamine (His), and phenethylamine (PEA) have been reported linked with intoxication. However, the destructive effect of these components on gut microbiota and liver is unclear. In this study, we found oral treatment of these components, especially His, stimulated the level of oxidative stress and inflammatory cytokines in liver and serum of mice. The gut microbiota community was changed and the level of lipopolysaccharide (LPS) increased significantly. Additionally, cellular pyroptosis pathway has been assessed and correlation analysis revealed a possible relationship between gut microbiota and liver pyroptosis. We speculated oral His treatment caused the reprogramming of gut microbiota metabolism, and increased LPS modulated the gut-liver interaction, resulting in liver pyroptosis, which might cause health risks. This study provided a theoretical basis for the effect of Huangjiu, facilitating the development of therapeutic and preventive strategies for related inflammatory disorders.
黄酒通常会导致快速醉酒，并且诸如β-苯乙醇（β-be）、异戊醇（Iso）、组胺（His）和苯乙胺（PEA）等成分已被报道与醉酒有关。然而，这些成分对肠道微生物群和肝脏的破坏作用尚不清楚。在本研究中，我们发现口服这些成分，尤其是His，会刺激小鼠肝脏和血清中的氧化应激水平和炎性细胞因子。肠道微生物群落发生了变化，脂多糖（LPS）水平显著升高。此外，还评估了细胞焦亡途径，相关性分析揭示了肠道微生物群与肝脏焦亡之间可能存在的关系。我们推测口服His治疗导致肠道微生物群代谢重编程，LPS增加调节了肠-肝相互作用，导致肝脏焦亡，这可能会引发健康风险。本研究为黄酒的作用提供了理论依据，有助于制定相关炎症性疾病的治疗和预防策略。
