College of Medicine, Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep, University of Nebraska Medical Center, Omaha, NE, United States.
Front Immunol. 2022 Aug 29;13:934617. doi: 10.3389/fimmu.2022.934617. eCollection 2022.
Alcohol use is known to alter the function of both innate and adaptive immune cells, such as neutrophils, macrophages, B cells, and T cells. Immune dysfunction has been associated with alcohol-induced end-organ damage. The role of innate lymphocytes in alcohol-associated pathogenesis has become a focus of research, as liver-resident natural killer (NK) cells were found to play an important role in alcohol-associated liver damage pathogenesis. Innate lymphocytes play a critical role in immunity and homeostasis; they are necessary for an optimal host response against insults including infections and cancer. However, the role of innate lymphocytes, including NK cells, natural killer T (NKT) cells, mucosal associated invariant T (MAIT) cells, gamma delta T cells, and innate lymphoid cells (ILCs) type 1-3, remains ill-defined in the context of alcohol-induced end-organ damage. Innate-like B lymphocytes including marginal zone B cells and B-1 cells have also been identified; however, this review will address the effects of alcohol misuse on innate T lymphocytes, as well as the consequences of innate T-lymphocyte dysfunction on alcohol-induced tissue damage.
饮酒已知会改变先天和适应性免疫细胞的功能，如中性粒细胞、巨噬细胞、B 细胞和 T 细胞。免疫功能障碍与酒精引起的终末器官损伤有关。先天淋巴细胞在酒精相关发病机制中的作用已成为研究的焦点，因为肝固有自然杀伤 (NK) 细胞被发现在酒精相关性肝损伤发病机制中发挥重要作用。先天淋巴细胞在免疫和稳态中发挥着关键作用；它们对于对抗包括感染和癌症在内的各种刺激的最佳宿主反应是必要的。然而，在酒精引起的终末器官损伤的情况下，包括 NK 细胞、自然杀伤 T (NKT) 细胞、黏膜相关不变 T (MAIT) 细胞、γδ T 细胞和先天淋巴细胞 (ILC) 1-3 在内的先天淋巴细胞的作用仍未得到明确界定。已鉴定出包括边缘区 B 细胞和 B1 细胞在内的先天样 B 淋巴细胞；然而，本综述将讨论酒精滥用对先天 T 淋巴细胞的影响，以及先天 T 淋巴细胞功能障碍对酒精引起的组织损伤的后果。
Zotero 插件
