Wang Ruifeng, Wang Yiping, Harris David C H, Cao Qi
Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Kidney Int. 2021 May;99(5):1077-1087. doi: 10.1016/j.kint.2020.11.023. Epub 2020 Dec 30.
It is well known that innate immune cells, including dendritic cells, macrophages, and natural killer cells, contribute to pathogenesis and protection in various kidney diseases. The understanding of innate immunity has been advanced recently by the discovery of a new group of innate lymphoid cells (ILCs), including ILC1, ILC2, and ILC3. ILCs lack adaptive antigen receptors, yet can be triggered by various pathogens and rapidly provide an abundant source of immunomodulatory cytokines to exert immediate immune reactions and direct subsequent innate and adaptive immune responses. ILCs play critical roles in immunity, tissue homeostasis, and pathological inflammation. In this review, we highlight the biological function of ILC subpopulations in the normal kidney, and their important roles in acute and chronic kidney diseases, thus demonstrating the emerging importance of ILC-regulated immunity in this special organ and providing insights for future research directions and therapeutic interventions.
众所周知，包括树突状细胞、巨噬细胞和自然杀伤细胞在内的固有免疫细胞在各种肾脏疾病的发病机制和保护过程中发挥作用。最近，通过发现一组新的固有淋巴细胞（ILC），包括ILC1、ILC2和ILC3，人们对固有免疫的认识取得了进展。ILC缺乏适应性抗原受体，但可被各种病原体触发，并迅速提供丰富的免疫调节细胞因子来源，以产生即时免疫反应并指导随后的固有免疫和适应性免疫反应。ILC在免疫、组织稳态和病理性炎症中发挥关键作用。在本综述中，我们重点介绍了ILC亚群在正常肾脏中的生物学功能，以及它们在急性和慢性肾脏疾病中的重要作用，从而证明了ILC调节的免疫在这个特殊器官中的重要性日益凸显，并为未来的研究方向和治疗干预提供了见解。
