Kedra H
Polim Med. 1986;16(1-2):31-43.
The experimental studies were undertaken in order to estimate the suitability of fibrin sealant in tracheal surgery and the compare tissue reactivity after using cyanoacrylic and fibrin adhesives. 14 piglets of the Poland white breed, weighing up to 25 kg, were used in the study. Under general tracheal anesthesis the tracheal wall was cut open by incision on the mid-line on the neck between the III-IV tubular cartilages along 3/4 of its circumference. The lips of the incision were closed by one atraumatic suture and tightened by fibrin sealant. Piglets dissecting examinations were carried out after 24 hours, 3, 7, 14, 30, 60 and 90 days after the operation. The results were estimated by macro- and microscopic studies. Comparative studies were carried out on the basis of our own similar experimental studies by means of cyanoacrylates. It was found that the Immuno fibrin adhesive is a very useful new material for tightening the tracheal wounds. The Immuno fibrin adhesive, in comparison with cyanoacrylates, has very good biological qualities, does not cause marginal tissue necrosis and increased chronic inflammatory changes. Fibrin sealant undergoes complete elimination from the wound after 7-10 days and is replaced by connective tissue.
进行实验研究是为了评估纤维蛋白密封剂在气管手术中的适用性，并比较使用氰基丙烯酸酯和纤维蛋白粘合剂后的组织反应性。研究使用了14只体重达25公斤的波兰白色品种仔猪。在全身气管麻醉下，沿颈部中线在第III - IV气管软骨之间，将气管壁切开其周长的3/4。切口边缘用一根无创伤缝线缝合，并用纤维蛋白密封剂加固。术后24小时、3天、7天、14天、30天、60天和90天对仔猪进行解剖检查。通过宏观和微观研究评估结果。在我们自己用氰基丙烯酸酯进行的类似实验研究基础上进行了比较研究。结果发现，免疫纤维蛋白粘合剂是一种用于加固气管伤口的非常有用的新材料。与氰基丙烯酸酯相比，免疫纤维蛋白粘合剂具有非常好的生物学特性，不会引起边缘组织坏死和慢性炎症变化增加。纤维蛋白密封剂在7 - 10天后从伤口完全清除，被结缔组织取代。
