Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain.
Department of Cardiology, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain.
Int J Environ Res Public Health. 2022 Mar 26;19(7):3961. doi: 10.3390/ijerph19073961.
Background (1): Headache is a prevalent symptom experienced during ongoing SARS-CoV-2 infection, but also weeks after recovery. Whether cardio-pulmonary dysfunction contributes causally to headache persistence is unknown. Methods (2): We conducted a case-control analysis nested in a prospective cohort study. Individuals were recruited from August 2020 to December 2020. Patients were grouped according to the presence or absence of long-COVID headache for three months after COVID-19 resolution. We compared demographic data, clinical variables, cardio-pulmonary laboratory biomarkers, quality of life, and cardio-pulmonary function between groups. Results (3): A cohort of 70 COVID-19 patients was evaluated. Patients with headaches (n = 10; 14.3%) were more frequently female (100% vs. 58.4%; = 0.011) and younger (46.9 ± 8.45 vs. 56.13 ± 12 years; = 0.023). No between-group differences in laboratory analysis, resting echocardiography, cardio-pulmonary exercise test, or pulmonary function tests were observed. Conclusion (4): In this exploratory study, no significant differences in cardio-pulmonary dysfunction were observed between patients with and without long-COVID headache during mid-term follow-up.
背景（1）：头痛是 SARS-CoV-2 感染期间以及康复后数周常见的症状。心肺功能障碍是否会导致头痛持续存在尚不清楚。方法（2）：我们进行了一项病例对照分析，嵌套在一项前瞻性队列研究中。研究对象于 2020 年 8 月至 2020 年 12 月期间招募。根据 COVID-19 康复后三个月是否存在长 COVID 头痛，将患者分为两组。我们比较了两组间的人口统计学数据、临床变量、心肺实验室生物标志物、生活质量和心肺功能。结果（3）：评估了 70 例 COVID-19 患者。有头痛的患者（n = 10；14.3%）更常为女性（100% vs. 58.4%； = 0.011）和年轻（46.9 ± 8.45 岁 vs. 56.13 ± 12 岁； = 0.023）。两组间实验室分析、静息超声心动图、心肺运动试验或肺功能检查无差异。结论（4）：在这项探索性研究中，在中期随访期间，长 COVID 头痛患者与无长 COVID 头痛患者的心肺功能障碍无显著差异。
