Centre for Patient Reported Outcomes Research, University of Birmingham, Edgbaston.
National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University of Birmingham.
Curr Opin Neurol. 2023 Dec 1;36(6):609-614. doi: 10.1097/WCO.0000000000001219. Epub 2023 Oct 3.
This is an expert overview of the recent literature on the nature, epidemiology, pathophysiology, impact, and management of COVID-19 related headache, in the acute phase of infection and in post-COVID-19 syndrome.
Headache is one of the commonest symptoms of COVID-19 during acute infection and it is often experienced by individuals who go on to develop long COVID. There is a higher prevalence of headache in individuals with long COVID who contracted the Delta variant than in those who were infected with the Wuhan or Alpha variants. Headaches related to COVID-19 infection are commoner and may be more intense in women.There are indications that presence of headache might indicate a more benign COVID-19 infection and a better chance of survival. However, the impact of COVID-19 related headache could be substantial leading to poor quality of life in individuals affected. Headache that changes in its nature in terms of frequency and severity should be investigated to exclude cerebrovascular complications. There are promising new therapies for its treatment, but further research is needed.
The findings of this review can promote a better understanding of COVID-19 related headache and guide clinicians in the management of patients.
本文是对 COVID-19 相关头痛的性质、流行病学、病理生理学、影响和管理的最新文献的专家综述，涵盖了感染急性期和 COVID-19 后综合征两个阶段。
头痛是 COVID-19 急性感染期间最常见的症状之一，而且经常发生在那些发展为长期 COVID 的患者中。与感染武汉或阿尔法变异株的患者相比，感染德尔塔变异株的长期 COVID 患者头痛的患病率更高。与 COVID-19 感染相关的头痛更为常见，在女性中可能更为剧烈。有迹象表明，头痛的存在可能表明 COVID-19 感染更为良性，患者存活的机会更大。然而，COVID-19 相关头痛的影响可能相当大，导致受影响个体的生活质量下降。头痛的性质、频率和严重程度发生变化，应进行调查以排除脑血管并发症。目前有一些有前途的新疗法，但仍需要进一步的研究。
本综述的结果可以促进对 COVID-19 相关头痛的更好理解，并为临床医生管理患者提供指导。
