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罕见的肠外阿米巴病病例。

A rare case of extraintestinal amebiasis.

机构信息

Department of Critical care Medicine, Affiliated Hospital of Zunyi Medical University, Dalian Road 149, Zunyi City, 563003, Guizhou, China.

Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi City, 563003, Guizhou, China.

出版信息

BMC Infect Dis. 2022 Apr 11;22(1):364. doi: 10.1186/s12879-022-07348-9.

DOI:10.1186/s12879-022-07348-9
PMID:35410146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9004190/
Abstract

BACKGROUND

Amoebiasis is caused by the protozoan Entamoeba histolytica, which is a rare infectious disease in developed countries. If the trophozoites enter the blood, it can spread through the body, such as brain, and lungs. Cases of simultaneous infection of multiple organs are extremely rare.

CASE PRESENTATION

Here we report a case of simultaneous infection of amoeba in pulmonary pleura, urinary system and central nervous system. Although the patient received anti amoeba treatment, the prognosis of the patient was poor.

CONCLUSIONS

In this patient, multiple extraintestinal amebic infections in the absence of clinically confirmed intestinal amebiasis or amebic liver abscess are rare and pose diagnostic challenges. The disseminated amebiasis has significantly increased the mortality. Early diagnosis and appropriate treatment may reduce the mortality of disseminated amebiasis.

摘要

背景

阿米巴病是由原生动物溶组织内阿米巴引起的,在发达国家是一种罕见的传染病。如果滋养体进入血液,它可以通过身体传播,如大脑和肺部。同时感染多个器官的病例极为罕见。

病例介绍

本文报告了一例肺胸膜、泌尿系统和中枢神经系统同时感染阿米巴的病例。尽管患者接受了抗阿米巴治疗,但患者的预后较差。

结论

在本例患者中,在无临床确诊的肠阿米巴病或肝阿米巴脓肿的情况下,出现多个肠外阿米巴感染较为罕见,且具有诊断挑战性。播散性阿米巴病显著增加了死亡率。早期诊断和适当的治疗可能会降低播散性阿米巴病的死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31a0/9004190/b5bb742477e9/12879_2022_7348_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31a0/9004190/b5bb742477e9/12879_2022_7348_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31a0/9004190/b5bb742477e9/12879_2022_7348_Fig1_HTML.jpg

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1
A rare case of extraintestinal amebiasis.罕见的肠外阿米巴病病例。
BMC Infect Dis. 2022 Apr 11;22(1):364. doi: 10.1186/s12879-022-07348-9.
2
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本文引用的文献

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Nasal septal abscess: Uncommon localization of extraintestinal amoebiasis.鼻中隔脓肿:肠外阿米巴病的罕见部位。
Braz J Otorhinolaryngol. 2021 Mar-Apr;87(2):241-243. doi: 10.1016/j.bjorl.2020.10.002. Epub 2020 Nov 5.
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Clinical Features and Gut Microbiome of Asymptomatic Entamoeba histolytica Infection.无症状溶组织内阿米巴感染的临床特征和肠道微生物组。
Clin Infect Dis. 2021 Nov 2;73(9):e3163-e3171. doi: 10.1093/cid/ciaa820.
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Urinary amoebiasis.
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Infect Dis Ther. 2024 Mar;13(3):625-632. doi: 10.1007/s40121-024-00934-1. Epub 2024 Mar 8.
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The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected Patient.诊断肠外阿米巴病的艰难之路:一例HIV感染患者的病例报告
Infect Drug Resist. 2023 Dec 8;16:7569-7574. doi: 10.2147/IDR.S442075. eCollection 2023.
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[Rare cause of necrotizing pneumonia : A case report].[坏死性肺炎的罕见病因:一例报告]
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Case Report: Lower Gastrointestinal Bleeding due to Detected Early by Multiplex PCR: Case Report and Review of the Laboratory Diagnosis of Amebiasis.病例报告:多重 PCR 早期检测到的下消化道出血:病例报告和阿米巴病实验室诊断综述。
Am J Trop Med Hyg. 2019 Dec;101(6):1380-1383. doi: 10.4269/ajtmh.19-0237.
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Intestinal amoebiasis: 160 years of its first detection and still remains as a health problem in developing countries.肠阿米巴病:首次发现至今已 160 年,在发展中国家仍然是一个健康问题。
Int J Med Microbiol. 2020 Jan;310(1):151358. doi: 10.1016/j.ijmm.2019.151358. Epub 2019 Sep 19.
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An underestimated sexually transmitted infection: amoebiasis.一种被低估的性传播感染:阿米巴病。
BMJ Case Rep. 2019 May 10;12(5):e228942. doi: 10.1136/bcr-2018-228942.
7
Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development.溶组织内阿米巴:临床特征、发病机制和疫苗研发的最新进展。
Can J Gastroenterol Hepatol. 2018 Dec 2;2018:4601420. doi: 10.1155/2018/4601420. eCollection 2018.
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Amebic Liver Abscess.阿米巴肝脓肿
N Engl J Med. 2018 Dec 6;379(23):2255. doi: 10.1056/NEJMicm1800360.
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Update on laboratory diagnosis of amoebiasis.关于阿米巴病的实验室诊断进展。
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10
A Review of the Global Burden, New Diagnostics, and Current Therapeutics for Amebiasis.阿米巴病的全球负担、新诊断方法及当前治疗手段综述
Open Forum Infect Dis. 2018 Jul 5;5(7):ofy161. doi: 10.1093/ofid/ofy161. eCollection 2018 Jul.