Department of Medical Oncology and Hematology, Kobe University Hospital, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan.
Department of Clinical Laboratory, Kobe University Hospital, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan.
BMC Infect Dis. 2022 Apr 11;22(1):367. doi: 10.1186/s12879-022-07341-2.
Cutibacterium modestum was named in 2020. C. modestum was previously called Propionibacterium humerusii. Several implant-associated infections caused by Cutibacterium species have been previously reported, but native vertebral osteomyelitis due to these bacteria has rarely been reported.
A 72-year-old man, who had previously received several nerve block injections for low back pain, was referred to our hospital for deterioration in back pain in the last 1 month. MRI findings were suggestive of L5-S1 vertebral osteomyelitis. Blood cultures and bone biopsy culture revealed the presence of Gram-positive bacilli. The isolate was identified as C. modestum by 16SrRNA gene sequencing. A diagnosis of vertebral osteomyelitis caused by C. modestum was made. Minocycline followed by oral amoxicillin was administered for 3 months. His symptom improved and did not recur after treatment completion.
A case of vertebral osteomyelitis caused by C. modestum was encountered. Although C. modestum is very similar to C. acnes, it could be accurately identified by 16SrRNA gene sequencing. This case represents the first documented C. modestum infection in humans.
小棒状杆菌于 2020 年命名。小棒状杆菌以前被称为肱动丙酸杆菌。已有几起因棒状杆菌引起的与植入物相关的感染被报道，但由这些细菌引起的原发性脊椎骨骨髓炎很少被报道。
一名 72 岁男性，此前因腰痛接受了多次神经阻滞注射治疗，因过去 1 个月腰痛恶化而被转至我院。MRI 检查结果提示 L5-S1 脊椎骨骨髓炎。血培养和骨活检培养显示存在革兰阳性杆菌。通过 16SrRNA 基因测序鉴定分离株为小棒状杆菌。诊断为小棒状杆菌引起的脊椎骨骨髓炎。给予米诺环素，随后口服阿莫西林治疗 3 个月。他的症状在治疗后得到改善，未再复发。
遇到了一例由小棒状杆菌引起的脊椎骨骨髓炎。虽然小棒状杆菌与痤疮丙酸杆菌非常相似，但通过 16SrRNA 基因测序可以准确识别。该病例代表了首例有记录的人类小棒状杆菌感染。
