Chopra Hitesh, Tsagkaris Christos, Matthews Lauren, Gautam Rupesh Kumar, Kamal Mohammad Amjad
Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.
University of Crete, Faculty of Medicine, Heraklion, Greece.
Curr Pharm Biotechnol. 2023;24(1):164-187. doi: 10.2174/1389201023666220411110358.
Skin is the largest non-parenchymal organ of the human body. It constitutes a natural barrier against pathogens and harmful environmental exposures and contributes to the human body's homeostasis. Conditions affecting the skin range from infections and injury to autoimmune diseases and cancer. Herbs have been used to treat dermatological conditions for a long time. Traditional approaches to delivering herbs to the skin include ointments, gels, creams, and lotions. However, poor lipophilicity or hydrophilicity in most herbal preparations results in limited bioavailability and poor penetration, restricting their effectiveness. Nanotechnology-based approaches have major potential, showing more promising results in enhancing transdermal penetration than traditional approaches. This review article summarizes such advances and sheds light on future directions in using nanotechnology-based strategies.
皮肤是人体最大的非实质器官。它构成了抵御病原体和有害环境暴露的天然屏障，并有助于人体的稳态。影响皮肤的病症范围从感染、损伤到自身免疫性疾病和癌症。草药长期以来一直用于治疗皮肤病。将草药递送至皮肤的传统方法包括软膏、凝胶、乳膏和洗剂。然而，大多数草药制剂中亲脂性或亲水性较差，导致生物利用度有限且渗透性差，限制了它们的有效性。基于纳米技术的方法具有很大潜力，在增强透皮渗透方面比传统方法显示出更有前景的结果。这篇综述文章总结了这些进展，并阐明了使用基于纳米技术的策略的未来方向。
