Zhong Zishao, Zhan Bingjie, Xu Baohui, Gao Hengjun
Tongji Hospital, School of Medicine, Tongji University Shanghai, China.
Institute of Digestive Disease, School of Medicine, Tongji University Shanghai, China.
Am J Cancer Res. 2022 Mar 15;12(3):1215-1221. eCollection 2022.
() infection is the most important risk factor for gastric cancer and plays an initiating role in the development of intestinal-type gastric cancer. Eradication of significantly reduces the incidence and mortality of gastric cancer. International expert consensus recommends eradication treatment for all infected individuals unless competing considerations. However, large-scale eradication treatments have led to increasing rates of resistance to multiple antibiotics, together with factors such as coccoid transformation, host CYP2C19 gene polymorphisms, and inappropriate treatment regimens, resulting in a gradual decline in eradication rates. Currently, empirical and repeated eradication of treatment is common in clinical practice, which will certainly lead to a further increase in antibiotic resistance, resulting in a great waste of medical resources and an increased psychological burden on patients and their relatives. Therefore, successful eradication of on initial treatment should be given high priority, and the implementation of personalized treatment is essential.
（）感染是胃癌最重要的危险因素，在肠型胃癌的发生中起启动作用。根除（该感染）可显著降低胃癌的发病率和死亡率。国际专家共识建议，除非有其他考量因素，所有感染个体均应接受根除治疗。然而，大规模的（该感染）根除治疗导致对多种抗生素的耐药率不断上升，再加上诸如球形转变、宿主CYP2C19基因多态性以及不恰当的治疗方案等因素，导致（该感染）根除率逐渐下降。目前，在临床实践中经验性和反复的（该感染）根除治疗很常见，这肯定会导致抗生素耐药性进一步增加，造成医疗资源的巨大浪费，并增加患者及其亲属的心理负担。因此，应高度重视初次治疗时成功根除（该感染），实施个性化治疗至关重要。
