Chawira A N, Warhurst D C, Peters W
Trans R Soc Trop Med Hyg. 1986;80(3):477-80. doi: 10.1016/0035-9203(86)90351-2.
Resistance to qinghaosu (artemisinin) developed rapidly in a chloroquine-resistant line of Plasmodium yoelii (NS) passaged in mice, but was not produced in chloroquine-sensitive P. berghei. Development of resistance took place in an apparently stepwise fashion. After removal of drug selection pressure some resistance was lost which was regained rapidly within three passages when drug pressure was reapplied. The resistant QS line was cross-resistant to two reduced derivatives of artemisinin but not to propoxycarbonyl dihydroartemisinin or artesunate. No significant resistance was shown against primaquine, pyrimethamine, cycloguanil or pyrimethamine-sulphadoxine, but resistance to chloroquine was enhanced and marked resistance to quinine, mefloquine and amodiaquine was noted. It is suggested that the unusual cross-resistance pattern of the strain relates to changes in membrane characteristics.
对青蒿素（青蒿琥酯）的耐药性在小鼠体内传代的氯喹耐药约氏疟原虫（NS）品系中迅速产生，但在氯喹敏感的伯氏疟原虫中未产生。耐药性的产生显然是逐步发生的。去除药物选择压力后，一些耐药性丧失，当重新施加药物压力时，在三代内迅速恢复。耐药的QS品系对青蒿素的两种还原衍生物交叉耐药，但对丙氧羰基二氢青蒿素或青蒿琥酯不耐药。对伯氨喹、乙胺嘧啶、环氯胍或乙胺嘧啶-磺胺多辛未表现出明显耐药，但对氯喹的耐药性增强，对奎宁、甲氟喹和阿莫地喹表现出明显耐药。提示该菌株不寻常的交叉耐药模式与膜特性的变化有关。
