Jacobo-Pinelli Regina, Guerrero-Paz Jose Alberto, Lugo-Machado Juan Antonio, Arvizu-Flores Jose Alberto, Guerrero-Paz Karen Paulina
Otolaryngology, Hospital de Especialidades No. 2 Instituto Mexicano del Seguro Social (IMSS), Ciudad Obregón, MEX.
Neurological Surgery, Hospital de Especialidades No. 2 Instituto Mexicano del Seguro Social (IMSS), Ciudad Obregón, MEX.
Cureus. 2022 Mar 9;14(3):e22991. doi: 10.7759/cureus.22991. eCollection 2022 Mar.
Skull base osteomyelitis (SBO) is a life-threatening condition in patients with underlying comorbidities. Ear infections may spread through normal skull base fissures in this group of patients. However, its diagnosis is frequently delayed due to the unspecific clinical findings at onset, such as headache, with diverse cranial neuropathies later as the disease progresses. We present the case of a patient with otogenic skull base osteomyelitis complicated with retropharyngeal extension, treated with surgical drainage and broad-spectrum antibiotics directed toward extended-spectrum beta-lactamase (ESBL)-producing , with recurrence of the infection three months later. With this case study, we aim to stress the importance of antimicrobial resistance and how it can preclude an otherwise favorable prognosis.
颅底骨髓炎（SBO）对于有基础合并症的患者来说是一种危及生命的疾病。耳部感染可能会通过这类患者正常的颅底裂隙扩散。然而，由于起病时临床症状不具特异性，如头痛，随着疾病进展后期会出现各种颅神经病变，其诊断常常被延误。我们报告一例耳源性颅底骨髓炎并发咽后扩展的患者，采用手术引流及针对产超广谱β-内酰胺酶（ESBL）细菌的广谱抗生素进行治疗，但3个月后感染复发。通过本病例研究，我们旨在强调抗菌药物耐药性的重要性以及它如何会妨碍原本良好的预后。
