De Carvalho Magali Rezende, Thomas Elmira, Shields-Johnson Barbara, Da Silva Ivan
Wound and Ostomy Department, Loyola University Medical Center, Maywood, USA.
Wound Care Department, The Loretto Hospital, Chicago, IL, USA.
Cureus. 2022 Mar 9;14(3):e23003. doi: 10.7759/cureus.23003. eCollection 2022 Mar.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the etiologic agent of coronavirus disease 2019 (COVID-19), causes an excessive inflammatory response and hemostatic abnormalities in the lungs, kidney, and skin. Four patients with COVID-19 admitted to an acute care community hospital developed nonblanchable purpuric macules, patches, and retiform purpura-like lesions at the sacrum, buttocks, lower extremities, and upper back. These lesions can be misdiagnosed as deep tissue pressure injuries. One patient also developed a vesicular-like rash at the upper back and another one developed pernio (chilblains)-like lesions to the third toe of the left foot. Previous studies suggest that the vascular hyperinflammation status and microthrombosis may be responsible for the cutaneous manifestations in patients with SARS-CoV-2. These cutaneous manifestations observed in patients with SARS-CoV-2 may be related to progression of the disease.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是2019冠状病毒病（COVID-19）的病原体，可在肺部、肾脏和皮肤引起过度炎症反应和止血异常。一家急症社区医院收治的4例COVID-19患者在骶部、臀部、下肢和上背部出现了不可压褪色的紫癜性斑疹、斑片及类网状紫癜样损害。这些损害可能会被误诊为深部组织压力性损伤。1例患者上背部还出现了水疱样皮疹，另1例患者左足第三趾出现了冻疮样损害。既往研究表明，血管高度炎症状态和微血栓形成可能是SARS-CoV-2感染患者皮肤表现的原因。在SARS-CoV-2感染患者中观察到的这些皮肤表现可能与疾病进展有关。
