Inoué S
Brain Dev. 1986;8(4):469-73. doi: 10.1016/s0387-7604(86)80071-7.
Time-consuming studies in search of an endogenously occurring sleep substance started early in this century. The historical background of this field of sleep science is briefly reviewed. The search for "sleep-promoting substance (SPS)" started in 1972. A bioassay technique was developed based on the monitoring of the circadian sleep-waking rhythm in freely moving male rats. The partially purified SPS from the brainstem of 24-h sleep-deprived rats caused a reduction in locomotor activity and an increase in both slow wave sleep and paradoxical sleep, when nocturnally administered by either the intraperitoneal or intracerebroventricular route. SPS is composed of at least 4 different effective fractions, including uridine. The sleep-inducing and sleep-maintaining potencies of several putative sleep substances were compared. Circadian variations in their effectiveness were apparent. The role of sleep substances in sleep regulation is discussed.
对内源性睡眠物质的耗时研究始于本世纪初。本文简要回顾了睡眠科学这一领域的历史背景。对“促睡眠物质（SPS）”的研究始于1972年。基于对自由活动雄性大鼠昼夜睡眠-觉醒节律的监测，开发了一种生物测定技术。当通过腹腔内或脑室内途径在夜间给药时，从24小时睡眠剥夺大鼠脑干中部分纯化的SPS会导致运动活动减少，慢波睡眠和异相睡眠增加。SPS至少由4种不同的有效成分组成，包括尿苷。比较了几种假定的睡眠物质的诱导睡眠和维持睡眠的效力。它们有效性的昼夜变化很明显。本文还讨论了睡眠物质在睡眠调节中的作用。
