Komoda Y, Honda K, Inoue S
Division of Molecular Biology, Tokyo Medical and Dental University, Japan.
Chem Pharm Bull (Tokyo). 1990 Jul;38(7):2057-9. doi: 10.1248/cpb.38.2057.
We previously reported regarding the "sleep-promoting substance (SPS)," which was isolated from the brainstem extract of sleep-deprived rats, the existence of multiple active components including uridine and SPS-B. Intracerebroventricular infusion of crude SPS-B exhibited significant enhancing effects on both slow wave sleep and paradoxical sleep in unrestrained rats. Further investigation of SPS-B has resulted in its final identification as oxidized glutathione (GSSG, gamma-glutamylcysteinylglycine disulfide). Authentic GSSG similarly administered in rats also significantly enhanced sleep which was indistinguishable from normal physiological sleep. We propose GSSG as a candidate endogenous sleep substance.
我们之前报道过从睡眠剥夺大鼠的脑干提取物中分离出的“促睡眠物质（SPS）”，它含有多种活性成分，包括尿苷和SPS-B。向未受限制的大鼠脑室内注入粗制SPS-B，对慢波睡眠和异相睡眠均有显著的增强作用。对SPS-B的进一步研究最终确定其为氧化型谷胱甘肽（GSSG，γ-谷氨酰半胱氨酰甘氨酸二硫化物）。同样给大鼠注射纯品GSSG也显著增强了睡眠，这与正常生理睡眠无异。我们提出GSSG作为内源性睡眠物质的一个候选物。
