Altria Client Services LLC, Center for Research and Technology, 601 E Jackson Street, Richmond, Virginia 23219, United States.
Chem Res Toxicol. 2022 May 16;35(5):782-791. doi: 10.1021/acs.chemrestox.1c00417. Epub 2022 Apr 13.
Tobacco-specific nitrosamine (TSNA) formation occurred during aerosol generation from select commercial cig-a-like e-cigarette products. To understand the drivers behind the potential formation of TSNAs in electronic cigarette (e-cigarette) aerosols and e-liquids, model e-liquid systems were generated in the lab to demonstrate that nitrite can react with nicotine and minor alkaloids to form TSNAs in e-liquids. In the presence of nitrite and nicotine, TSNA levels in e-liquids increased over time and the process was accelerated by elevated temperature. Additionally, TSNAs formed during aerosol generation when nitrite was present in the corresponding e-liquids. The commercial e-cigarette products that showed higher levels and formation of TSNAs were observed to contain nitrite and minor alkaloid impurities in the corresponding e-liquids. This study provides valuable information about drivers for TSNA formation in e-liquids and e-cigarette aerosols that may be applied to the evaluation and quality assurance of e-cigarette products.
从选定的商业类似雪茄电子烟产品中产生气溶胶时会发生烟草特异性亚硝胺（TSNA）形成。为了了解电子烟（电子烟）气溶胶和电子烟液中潜在形成 TSNAs 的驱动因素，在实验室中生成了模型电子烟液系统，以证明亚硝酸盐可以与尼古丁和少量生物碱反应，在电子烟液中形成 TSNAs。在亚硝酸盐和尼古丁存在的情况下，电子烟液中的 TSNA 水平随时间增加，并且温度升高会加速该过程。此外，当相应电子烟液中存在亚硝酸盐时，在气溶胶生成过程中也会形成 TSNAs。观察到含有更高水平和形成 TSNAs 的商业电子烟产品在相应电子烟液中含有亚硝酸盐和少量生物碱杂质。这项研究提供了有关电子烟液和电子烟气溶胶中 TSNA 形成的驱动因素的有价值信息，这些信息可应用于电子烟产品的评估和质量保证。
