School of Pharmacy, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, Shenzhen, 518057, China.
J Cardiovasc Transl Res. 2022 Jun;15(3):456-468. doi: 10.1007/s12265-022-10252-x. Epub 2022 Apr 13.
Extracellular vesicles (EVs), including exosomes and microvesicles, emerge to be crucial mediators of cell-to-cell communication in multiple organs. Non-coding RNAs loaded inside EVs contribute as one major mechanism for remote information transfer among different cell types or organs. Increasing evidence suggests that EV-associated non-coding RNAs derived from cardiovascular or non-cardiac cells regulate cardiovascular pathophysiology in heart development and diseases. The functional relevance of the EV-associated ncRNAs in heart diseases provides an avenue to develop novel diagnostic tools and therapies for heart diseases. In this review, we summarize the recent advancement of EV-associated ncRNAs in different cardiovascular diseases, including myocardial infarction, arrhythmias, cardiac hypertrophy, and heart failure, with an emphasis on the underlying molecular mechanisms.
细胞外囊泡 (EVs)，包括外泌体和微囊泡，被认为是多种器官中细胞间通讯的重要介质。EV 内装载的非编码 RNA 作为不同细胞类型或器官之间远程信息传递的主要机制之一。越来越多的证据表明，来源于心血管或非心肌细胞的 EV 相关非编码 RNA 调节心脏发育和疾病中的心血管病理生理学。EV 相关 ncRNA 在心脏疾病中的功能相关性为心脏疾病的新型诊断工具和治疗方法的发展提供了途径。在这篇综述中，我们总结了 EV 相关 ncRNA 在不同心血管疾病中的最新进展，包括心肌梗死、心律失常、心肌肥厚和心力衰竭，并强调了潜在的分子机制。
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