Department of Pathology, Peking University Cancer Hospital, Beijing, China.
Department of Pathology, Alaska Native Medical Center, Anchorage, AK, USA.
BMC Womens Health. 2022 Apr 14;22(1):119. doi: 10.1186/s12905-022-01700-6.
Breast leiomyoma is a rare benign mesenchymal tumor, accounting for less than 1% of all breast neoplasms. Cases of breast atypical leiomyoma is even more rarely reported and its diagnostic criteria together with its clinical courses is not cleared defined.
We described two patients with breast leiomyomas. One has unilateral benign breast leiomyoma, the other one has bilateral breast leiomyomas. For the bilateral case, the left-side tumor was diagnosed as benign leiomyoma while the right-side tumor was diagnosed as atypical leiomyoma. The morphological features that lead to the diagnosis of atypical leiomyoma are its invasive growth pattern, mild nuclear atypia, and mitotic figures up to 3mitoses/10HPF.
Atypical breast leiomyoma appears to behave like benign leiomyoma without recurrence in our study with nine-year follow-up. Due to the limited experience, cases presented as atypical intraparenchymal breast leiomyoma should be closely followed.
乳腺平滑肌瘤是一种罕见的良性间叶性肿瘤，占所有乳腺肿瘤的不到 1%。乳腺非典型平滑肌瘤的病例更为罕见，其诊断标准及其临床过程尚不清楚。
我们描述了两名患有乳腺平滑肌瘤的患者。其中 1 例为单侧良性乳腺平滑肌瘤，另 1 例为双侧乳腺平滑肌瘤。对于双侧病例，左侧肿瘤诊断为良性平滑肌瘤，而右侧肿瘤诊断为非典型平滑肌瘤。导致诊断为非典型平滑肌瘤的形态特征是其浸润性生长模式、轻度核异型性和核分裂象高达每 10 高倍视野 3 个。
在我们的研究中，9 年的随访结果显示，非典型乳腺平滑肌瘤的表现与良性平滑肌瘤相似，无复发。由于经验有限，对于表现为非典型乳腺实质内平滑肌瘤的病例应密切随访。
