Department of Nephrology, Jiujiang First People's Hospital, Jiujiang 332000, China.
Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China.
J Healthc Eng. 2022 Apr 5;2022:1469370. doi: 10.1155/2022/1469370. eCollection 2022.
In order to compare the effects of iopromide and isoxazole on postoperative contrast-induced nephropathy in patients with renal insufficiency, the paper searches for randomized controlled trials and retrospective cohort studies comparing the effects of iopromide and iodixanol on renal function in patients with renal insufficiency after surgery. The data are extracted from eligible studies. We tried to assess the incidence of contrast-agent nephropathy, preoperative and postoperative serum creatinine indicators, and mortality. This paper includes 8 studies with a total of 1243 patients. The incidence of contrast-induced nephropathy in the iopromide group is higher than that in the iodixanol group, and there is no significant difference between the two groups in postoperative mortality and preoperative serum creatinine expression. Sensitivity analysis and funnel chart show that our research is robust and has low publication bias. Our research shows that in patients with renal insufficiency, the incidence of contrast-medium nephropathy in the iopromide group is higher than that in the iodixanol group. Iodixanol is safer and has less effect on patients' serum creatinine levels.
为了比较碘普罗胺和异噁唑对肾功能不全患者术后对比剂诱导肾病的影响，本文检索了比较碘普罗胺和碘昔醇对肾功能不全患者术后肾功能影响的随机对照试验和回顾性队列研究。从合格的研究中提取数据。我们试图评估对比剂肾病的发生率、术前和术后血肌酐指标以及死亡率。本文包括 8 项研究，共 1243 例患者。碘普罗胺组的对比剂肾病发生率高于碘昔醇组，两组术后死亡率和术前血肌酐表达无显著差异。敏感性分析和漏斗图表明，我们的研究结果稳健，发表偏倚低。我们的研究表明，在肾功能不全患者中，碘普罗胺组的对比剂肾病发生率高于碘昔醇组。碘昔醇更安全，对患者的血肌酐水平影响较小。
