Feng Xuan, Bello Davide, O'Hagan David
School of Chemistry, University of St Andrews North Haugh, St Andrews, Fife, KY16 9ST UK
RSC Adv. 2021 Jan 28;11(10):5291-5294. doi: 10.1039/d1ra00235j.
The isolation of three adenosine based metabolites 6-8 from is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts.
据报道,从[具体来源未给出]中分离出了三种基于腺苷的代谢产物6 - 8。这些代谢产物在结构上与含氟抗生素杀结核菌素1以及最近鉴定出的两种糖基化氟代腺苷2和3相关,然而在这种情况下,这三种代谢产物不含氟,这表明生成含氟代谢产物的生物合成酶也能处理其非氟化的对应物。