3'--β-葡萄糖基-4',5'-二去氢-5'-脱氧腺苷是核苷菌素产生菌的天然产物。
3'--β-Glucosyl-4',5'-didehydro-5'-deoxyadenosine Is a Natural Product of the Nucleocidin Producers and .
机构信息
School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, U.K.
EaStChem School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, U.K.
出版信息
J Nat Prod. 2023 Oct 27;86(10):2326-2332. doi: 10.1021/acs.jnatprod.3c00521. Epub 2023 Sep 25.
3'--β-Glucosyl-4',5'-didehydro-5'-deoxyadenosine is identified as a natural product of and . It is also generated by direct β-glucosylation of 4',5'-didehydro-5'-deoxyadenosine with the enzyme NucGT. The intact incorporation of oxygen-18 and deuterium isotopes from (±)[1-O,1-H]-glycerol into C-5' of nucleocidin and its related metabolites precludes 3'--β-glucosyl-4',5'-didehydro-5'-deoxyadenosine as a biosynthetic precursor to nucleocidin .
3'--β-葡萄糖基-4',5'-二去氢-5'-脱氧腺苷被鉴定为 和 的天然产物。它也是通过酶 NucGT 直接将 4',5'-二去氢-5'-脱氧腺苷β-葡萄糖化生成的。（±）[1-O,1-H]-甘油中的氧-18 和氘同位素完全掺入到核菌素及其相关代谢物的 C-5'中，排除了 3'--β-葡萄糖基-4',5'-二去氢-5'-脱氧腺苷作为核菌素的生物合成前体。
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