Pan Zilong, Liu Luhua, Xu Senmiao, Shen Zhenlu
College of Chemical Engineering, Zhejiang University of Technology Hangzhou 310014 China
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Science, Suzhou Research Institute, Lanzhou Institute of Chemical Physics, Chinese Academy of Science Lanzhou 730000 China
RSC Adv. 2021 Jan 29;11(10):5487-5490. doi: 10.1039/d0ra10211c. eCollection 2021 Jan 28.
We herein report a ligand-free Ir-catalyzed C-H borylation of -acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C-B bonds could be easily converted to C-C and C-heteroatom bonds.
我们在此报告一种无配体铱催化的酰基保护吲哚的C-H硼化反应。这种简单的方法能够耐受多种官能团，以良好的产率和优异的区域选择性得到C3硼化吲哚。我们还证明了当前方法适用于克级硼化反应，并且C-B键能够容易地转化为C-C键和C-杂原子键。
