Wood Elizabeth K, Sullivan Elinor L
Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239.
Oregon National Primate Research Center, 505 NW 185 Avenue, Beaverton, OR 97006.
Curr Opin Endocr Metab Res. 2022 Jun;24. doi: 10.1016/j.coemr.2022.100336. Epub 2022 Feb 26.
The macro and micronutrient composition and the overall quantity of the diet are important predictors of physical and psychological health and, as a consequence, behavior. Translational preclinical models are critical to identifying the mechanisms underlying these relationships. Nonhuman primate models are particularly instrumental to this line of research as they exhibit considerable genetic, social, and physiological similarities, as well as similarities in their developmental trajectories to humans. This review aims to discuss recent contributions to the field of diet and metabolism and health using nonhuman primate models. The influence of diet composition on health and physiology across the lifespan will be the primary focus, including recent work examining the impact of maternal diet programming of offspring physiologic and behavioral developmental outcomes.
饮食中的宏量和微量营养素组成以及饮食总量是身心健康以及行为的重要预测指标。转化临床前模型对于确定这些关系背后的机制至关重要。非人灵长类动物模型在这一研究领域特别有用，因为它们在基因、社会和生理方面表现出相当大的相似性，并且在发育轨迹上也与人类相似。本综述旨在讨论使用非人灵长类动物模型在饮食、代谢与健康领域的最新研究成果。饮食组成对整个生命周期健康和生理的影响将是主要关注点，包括最近研究母体饮食对后代生理和行为发育结果影响的工作。
