School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Nutr Metab Cardiovasc Dis. 2022 Jun;32(6):1343-1352. doi: 10.1016/j.numecd.2022.03.003. Epub 2022 Mar 7.
Diastolic dysfunction is the decreased flexibility of the left ventricle due to the impaired ability of the myocardium to relax and plays an important role in the pathogenesis of heart failure. Lipid metabolism is a well-known contributor to cardiac conditions, including ventricular function. In this article, we aimed to review the literature addressing the connections between lipids, their storage, and metabolism with left ventricular diastolic dysfunction.
We searched Google scholar, Pubmed, Embase and Researchgate for our keywords: "Diastolic function", "Fat" and "Lipid profile". Initially, 250 articles were selected by title and 84 of them were chosen as most relevant and directly reviewed.
Alterations of lipid metabolism in cardiac muscle and cardiac lipid content can occur in many conditions, including consumption of a high-fat diet, obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). These conditions induce alterations in myocardial lipid metabolism, increase myocardial fat content and epicardial fat thickness and increase inflammation and oxidative stress which ultimately lead to cardiac lipotoxicity and diastolic dysfunction. The effects of lipids on diastolic function can differ based on gender. Lipid profile and metabolism are as important in the pathogenesis of diastolic dysfunction as they are in other cardiovascular disorders. A more careful look at cardiac lipid metabolism in molecular, histological and gross levels results in more precise understanding of its role in myocardial function and leads to development of potential treatments for diastolic dysfunction.
舒张功能障碍是由于心肌松弛能力受损导致左心室顺应性降低，在心力衰竭的发病机制中起重要作用。脂质代谢是心脏疾病的已知诱因之一，包括心室功能。本文旨在综述脂质及其储存和代谢与左心室舒张功能障碍之间联系的文献。
我们在 Google scholar、Pubmed、Embase 和 Researchgate 上搜索了我们的关键词：“舒张功能”、“脂肪”和“脂质谱”。最初，通过标题选择了 250 篇文章，其中有 84 篇被选为最相关和直接的综述。
心肌和心脏脂质含量的脂质代谢改变可发生在多种情况下，包括高脂肪饮食、肥胖、代谢综合征和非酒精性脂肪肝（NAFLD）。这些情况会导致心肌脂质代谢改变、心肌脂肪含量和心外膜脂肪厚度增加，并增加炎症和氧化应激，最终导致心脏脂肪毒性和舒张功能障碍。脂质对舒张功能的影响可能因性别而异。脂质谱和代谢在舒张功能障碍的发病机制中与其他心血管疾病一样重要。更仔细地观察心脏脂质代谢在分子、组织学和大体水平上，可以更精确地了解其在心肌功能中的作用，并为舒张功能障碍的潜在治疗方法的发展提供依据。
