Department of Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.
School of Veterinary Sciences, Massey University, Stillwater, Palmerston North, New Zealand.
J Vet Intern Med. 2022 May;36(3):1131-1138. doi: 10.1111/jvim.16421. Epub 2022 Apr 16.
Both obesity and metabolic syndrome are associated with hypercoagulability in people, increasing the risk of cardiovascular disease and thromboembolic events. Whether hypercoagulability exists in obese, insulin-dysregulated horses is unknown.
HYPOTHESIS/OBJECTIVES: To determine if coagulation profiles differ between healthy horses and those with obesity and insulin dysregulation.
Fifteen healthy horses (CON) and 15 obese, insulin-dysregulated horses (OBID). Individuals were university or client owned.
Case-control study. Obesity was defined as a body condition score (BCS) ≥7.5/9 (modified Henneke scale). Insulin dysregulation status was assessed by an oral sugar test (OST). Kaolin-thromboelastography and traditional coagulation variables were compared between groups. The direction and strength of the association between coagulation variables and BCS and OST results were determined using Spearman's correlation.
Thromboelastography variables MA (OBID: 69.5 ± 4.5 mm; CON: 64.8 ± 4.3 mm; P = .007) and G-value (OBID: 11749 ± 2536 dyn/m ; CON: 9319 ± 1650 dyn/m ; P = .004) were higher in OBID compared to CON. Positive correlations between MA and BCS (R = 0.45, P = .01) and serum insulin (T : R = 0.45, P = .01; T : R = 0.39, P = .03), and G-value and BCS (R = 0.46, P = .01), and serum insulin (T : R = 0.48, P = .007; T : R = 0.43, P = .02; T : R = 0.38, P = .04) were present.
Obese, insulin-dysregulated horses are hypercoagulable compared to healthy controls.
肥胖和代谢综合征都会导致人体出现高凝状态，增加心血管疾病和血栓栓塞事件的风险。肥胖和胰岛素功能紊乱的马是否存在高凝状态尚不清楚。
假设/目的：确定健康马与肥胖和胰岛素功能紊乱马的凝血谱是否存在差异。
15 匹健康马（CON）和 15 匹肥胖、胰岛素功能紊乱的马（OBID）。个体来自大学或客户所有。
病例对照研究。肥胖定义为体况评分（BCS）≥7.5/9（改良 Henneke 量表）。胰岛素功能紊乱状态通过口服糖耐量试验（OST）进行评估。比较两组之间高岭土血栓弹性描记法和传统凝血变量。使用 Spearman 相关分析确定凝血变量与 BCS 和 OST 结果之间的关联方向和强度。
血栓弹性描记术变量 MA（OBID：69.5±4.5 毫米；CON：64.8±4.3 毫米；P=0.007）和 G 值（OBID：11749±2536 dyn/m；CON：9319±1650 dyn/m；P=0.004）在 OBID 中高于 CON。MA 与 BCS（R=0.45，P=0.01）和血清胰岛素（T：R=0.45，P=0.01；T：R=0.39，P=0.03）呈正相关，G 值与 BCS（R=0.46，P=0.01）和血清胰岛素（T：R=0.48，P=0.007；T：R=0.43，P=0.02；T：R=0.38，P=0.04）呈正相关。
与健康对照组相比，肥胖和胰岛素功能紊乱的马存在高凝状态。
