男性割礼与男性及其女性性伴侣的人乳头瘤病毒（HPV）感染：异性活动（HITCH）队列研究中 HPV 感染和传播的夫妇研究结果。

Male Circumcision and Genital Human Papillomavirus (HPV) Infection in Males and Their Female Sexual Partners: Findings From the HPV Infection and Transmission Among Couples Through Heterosexual Activity (HITCH) Cohort Study.

机构信息

Division of Cancer Epidemiology, Department of Oncology, McGill University, Montréal, Quebec, Canada.

Department of Family and Community Medicine and MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.

出版信息

J Infect Dis. 2022 Sep 28;226(7):1184-1194. doi: 10.1093/infdis/jiac147.

DOI:10.1093/infdis/jiac147

PMID:35429378

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10233487/

Abstract

BACKGROUND

Previous studies examining the association between male circumcision (MC) and human papillomavirus (HPV) infections have reported inconsistent results. We used data from the HPV Infection and Transmission Among Couples Through Heterosexual Activity (HITCH) cohort study to examine the association between MC and HPV infections in males and their female sexual partners.

METHODS

We enrolled monogamous couples in a longitudinal study between 2005 and 2011 in Montreal, Canada. We used logistic and Poisson regression models with propensity score adjustment to estimate odds ratios (ORs) and rate ratios for the association between MC and the prevalence, transmission, and clearance of HPV infections.

RESULTS

Four hundred thirteen couples were included in our study. The prevalence OR for the association between MC and baseline infections was 0.81 (95% confidence interval [CI], .56-1.16) in males and 1.05 (95% CI, .75-1.46) in females. The incidence rate ratio for infection transmission was 0.59 (95% CI, .16-2.20) for male-to-female transmission and 0.77 (95% CI, .37-1.60) for female-to-male transmission. The clearance rate ratio for clearance of infections was 0.81 (95% CI, .52-1.24).

CONCLUSIONS

We found little evidence of an association between MC and HPV infection prevalence, transmission, or clearance in males and females. Further longitudinal couple-based studies are required to investigate this association.

摘要

背景

之前研究男性割礼（MC）与人类乳头瘤病毒（HPV）感染之间的关联的研究结果并不一致。我们使用 HPV 通过异性性行为感染和传播的夫妇研究（HITCH）队列研究的数据，来检验 MC 与男性及其女性性伴侣 HPV 感染之间的关系。

方法

我们在 2005 年至 2011 年期间在加拿大蒙特利尔招募了一对对一夫一妻制的夫妇。我们使用具有倾向评分调整的逻辑和泊松回归模型来估计 MC 与 HPV 感染的流行率、传播和清除之间的关联的优势比（OR）和比率比。

结果

我们的研究共纳入了 413 对夫妇。在男性中，MC 与基线感染之间的关联的患病率 OR 为 0.81（95%置信区间[CI]，.56-1.16），在女性中为 1.05（95%CI，.75-1.46）。感染传播的发病率比值比为 0.59（95%CI，.16-2.20），用于男性到女性的传播，为 0.77（95%CI，.37-1.60），用于女性到男性的传播。感染清除的清除率比值比为 0.81（95%CI，.52-1.24）。