State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing, 210096, P. R. China.
ChemMedChem. 2022 Jul 5;17(13):e202200003. doi: 10.1002/cmdc.202200003. Epub 2022 May 27.
Carbon dots are small carbon nanoparticles with intrinsic photoluminescence. Because of the advantages such as good biocompatibility and water dispersity, many researchers have applied carbon dots as delivery platforms of antimicrobial agents. Compared with the free small-molecule antimicrobial agents alone, the carbon dot-based systems may exhibit enhanced antimicrobial activity, increased stability, improved cellular uptake, and reduced side effects. This review will mainly discuss the antimicrobial agent-loaded carbon dots for various antibacterial, antifungal, and antiviral applications. The current limitations and future research directions in the related field are also proposed. It is hoped that this review will have implications for the future development of functional carbon dots for various practical antimicrobial uses.
碳点是具有本征光致发光的小碳纳米粒子。由于具有良好的生物相容性和水分散性等优点，许多研究人员将碳点用作抗菌剂的递送平台。与单独的游离小分子抗菌剂相比，基于碳点的系统可能表现出增强的抗菌活性、增加的稳定性、改善的细胞摄取和减少的副作用。本综述将主要讨论负载抗菌剂的碳点在各种抗菌、抗真菌和抗病毒应用中的应用。还提出了相关领域目前的局限性和未来的研究方向。希望本综述对未来功能性碳点在各种实际抗菌用途中的发展具有启示意义。
