Pathogen Biological Inspection Department, Changzhou center for disease control and prevention center, Changzhou, Jiangsu, China.
Tianning district center for disease control and prevention, Changzhou, Jiangsu, China.
Int J Infect Dis. 2022 Jul;120:83-87. doi: 10.1016/j.ijid.2022.04.020. Epub 2022 Apr 14.
The non-O1/non-O139 Vibrio cholerae caused outbreaks or sporadic cases of gastroenteritis that was rarely seen in good sanitary condition. It was described a case of systemic multiple organ lesions that worsened because of non-O1/non-O139 V. cholerae, suggesting that serogroups have a potential virulence in enhancing pathogenicity with patients with underlying diseases compared with a healthy population.
Samples are identified by strain culture, polymerase chain reaction (PCR) virulence identification, and whole genome sequencing.
A middle-aged man was diagnosed with cytotoxin-producing and nontoxin V. cholerae non-O1/non-O139 serogroups. Although lacking the CT toxin encoded by ctxAB gene, the pathogenesis of cholera relies on the synergistic action of many other genes, especially virulence genes.
This case suggested that the laborers engaging in agricultural production are at potential risk of V. cholerae infection by exposure of open wounds to contaminated water . However, epidemiological investigation should focus on the objective cause of the change of working environment. Furthermore, common diseases can possibly enhance the virulence of non-O1/non-O139 serogroups by attacking the tight junction of small intestinal epithelial cells, further triggering bacteremia, a process that may lead to death within 48-72 hours, which requires great attention.
非 O1/非 O139 霍乱弧菌引起的肠胃炎暴发或散发病例在卫生条件良好的情况下很少见。本文描述了一例全身性多器官损伤的病例，由于非 O1/非 O139 霍乱弧菌感染而恶化，这表明与健康人群相比，血清群在增强有基础疾病患者的致病性方面具有潜在的毒力。
通过菌株培养、聚合酶链反应（PCR）毒力鉴定和全基因组测序进行鉴定。
一名中年男子被诊断为产细胞毒素和非产毒素的非 O1/非 O139 霍乱弧菌血清群。尽管缺乏 ctxAB 基因编码的 CT 毒素，但霍乱的发病机制依赖于许多其他基因的协同作用，特别是毒力基因。
本病例提示从事农业生产的劳动者因开放性伤口暴露于污染水中而有感染非 O1/非 O139 霍乱弧菌的潜在风险。然而，流行病学调查应重点关注工作环境变化的客观原因。此外，常见疾病可能通过攻击小肠上皮细胞的紧密连接，进一步引发菌血症，从而增强非 O1/非 O139 血清群的毒力，这可能导致在 48-72 小时内死亡，需要高度重视。
