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莱姆病致北美儿童神经根神经炎。

Radiculoneuritis due to Lyme disease in a North American child.

机构信息

Division of Emergency Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, United States of America; Department of Pediatrics, Harvard Medical School, 25 Shattuck Street, Boston, MA, United States of America.

Division of Emergency Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, United States of America; Department of Pediatrics, Harvard Medical School, 25 Shattuck Street, Boston, MA, United States of America.

出版信息

Am J Emerg Med. 2022 Jul;57:234.e1-234.e2. doi: 10.1016/j.ajem.2022.03.063. Epub 2022 Apr 7.

DOI:10.1016/j.ajem.2022.03.063
PMID:35430099
Abstract

Lyme disease is the most frequently reported vector-borne illness in the United States. It is caused by infection with Borrelia burgdorferi via the bite of an infected blacklegged tick (Ixodes spp.) Lyme disease has three stages: early localized, early disseminated, and late. Early disseminated Lyme disease may include neurologic manifestations such as cranial nerve palsy, meningitis, and radicular pain (also called radiculoneuritis). Isolated radiculoneuritis is a rare presentation of early disseminated Lyme disease and is likely underrecognized. We report a case of isolated Lyme radiculoneuritis in a child in Massachusetts characterized by fever and allodynia of the upper back that was treated in the emergency department. Laboratory investigation demonstrated elevated inflammatory markers and positive Lyme testing. Magnetic resonance imaging with gadolinium contrast revealed nerve root enhancement in C5-C6 and C6-C7. The symptoms resolved with oral doxycycline. Neuropathic pain should raise suspicion for neurologic manifestations of Lyme disease in North America even in the absence of meningitis and cranial nerve palsy. We report how timely recognition of this rare syndrome in North America is important and may prevent progression to late disease.

摘要

莱姆病是美国报告最多的虫媒传染病。它是由感染伯氏疏螺旋体通过受感染的黑腿蜱(Ixodes 属)叮咬引起的。莱姆病有三个阶段:早期局部、早期播散和晚期。早期播散性莱姆病可能包括颅神经麻痹、脑膜炎和神经根痛(也称为神经根神经炎)等神经系统表现。孤立性神经根神经炎是早期播散性莱姆病的罕见表现,可能认识不足。我们报告了马萨诸塞州一例儿童孤立性莱姆神经根神经炎病例,表现为发热和上背部感觉异常,在急诊科接受治疗。实验室检查显示炎症标志物升高和莱姆病检测阳性。钆增强磁共振成像显示 C5-C6 和 C6-C7 神经根增强。症状随口服多西环素而缓解。神经病理性疼痛应引起对北美的莱姆病神经系统表现的怀疑,即使没有脑膜炎和颅神经麻痹。我们报告了在北美及时认识到这种罕见综合征的重要性,这可能防止疾病进展至晚期。

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Am J Emerg Med. 2022 Jul;57:234.e1-234.e2. doi: 10.1016/j.ajem.2022.03.063. Epub 2022 Apr 7.
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