Neonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, Piraeus, Greece.
Neonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, Piraeus, Greece.
Blood Rev. 2022 Sep;55:100951. doi: 10.1016/j.blre.2022.100951. Epub 2022 Apr 11.
Although fresh frozen plasma (FFP) transfusions are common practice in neonatology, robust evidence on their use is lacking. The aim of this study was to systematically review the literature for data on the practice of FFP transfusions in neonates and their association with neonatal morbidity and mortality. The authors identified 40 studies, which met the inclusion criteria for this review. It was demonstrated that the practice of FFP transfusions significantly varies throughout the world. The majority of FFP transfusions are administered "prophylactically", without evidence of active bleeding. Although FFP transfusions may restore coagulation tests results, they do not alter the clinical outcome of the neonates. Reactions following transfusions are probably underestimated in neonates, often undiagnosed and thus, underreported. High quality RCTs aiming to evaluate the effectiveness of FFP in specific clinical conditions are urgently needed, as they could change long-standing FFP transfusion practices, and help reduce neonatal morbidity and mortality.
虽然新鲜冷冻血浆（FFP）输注在新生儿学中是常见的做法，但缺乏关于其使用的有力证据。本研究旨在系统地回顾文献中关于新生儿 FFP 输注的实践及其与新生儿发病率和死亡率的关系的数据。作者确定了 40 项符合本综述纳入标准的研究。结果表明，FFP 输注的做法在世界各地差异很大。大多数 FFP 输注是“预防性”给予的，没有明显的出血证据。虽然 FFP 输注可能会恢复凝血试验结果，但它们并不能改变新生儿的临床结局。新生儿输血后的反应可能被低估，往往无法诊断，因此报告不足。迫切需要高质量的 RCT 来评估 FFP 在特定临床情况下的有效性，因为这可能改变长期以来的 FFP 输注实践，并有助于降低新生儿发病率和死亡率。
