Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Am J Med Sci. 2022 Sep;364(3):296-303. doi: 10.1016/j.amjms.2022.04.009. Epub 2022 Apr 14.
Estimates of the prevalence of SARS-CoV-2 antibodies and factors associated with infection among healthcare personnel (HCP) vary widely. We conducted a serosurvey of HCP at a large public healthcare system in the Atlanta area.
All employees of Grady Health System were invited to participate in mid-2020; a volunteer sample of those completing testing was included. Asymptomatic HCP were offered testing for IgG antibody and for SARS-CoV-2 RNA using polymerase chain reaction (PCR). Symptomatic HCP were offered PCR testing. Antibody index values for IgG and cycle threshold values for PCR were evaluated for those with a positive result. An online survey was distributed at the time of testing.
624 of 1677 distributed surveys (37.2%) were completed by 608 unique HCP. The majority were female (76.4%) and provided clinical care (70.9%). The most common occupations were clinician (24.8%) and nurse (23.5%). 37 of 608 (6.1%) HCP had detectable IgG. Exposure to a confirmed case of COVID-19 outside of the hospital was associated with detectable IgG (12.8% vs 4.4%, p = 0.02), but exposure to a patient with COVID-19 was not.
Among HCP in a large healthcare system, 6.1% had detectable SARS-CoV-2 IgG. Seropositivity was associated with exposures outside of the healthcare setting.
医护人员（HCP）中 SARS-CoV-2 抗体的流行率和感染相关因素的估计值差异很大。我们在亚特兰大地区的一家大型公共医疗保健系统中对 HCP 进行了血清学调查。
邀请 Grady 卫生系统的所有员工参加 2020 年中期的研究；对完成检测的人员进行了志愿者样本的纳入。对无症状的 HCP 提供 IgG 抗体和 SARS-CoV-2 RNA 的聚合酶链反应（PCR）检测。对有症状的 HCP 提供 PCR 检测。对有阳性结果的人评估 IgG 的抗体指数值和 PCR 的循环阈值值。在检测时分发了在线调查。
在分发的 1677 份调查中，有 624 份（37.2%）由 608 名独特的 HCP 完成。大多数是女性（76.4%）并提供临床护理（70.9%）。最常见的职业是临床医生（24.8%）和护士（23.5%）。608 名 HCP 中有 37 名（6.1%）可检测到 IgG。与医院外确诊的 COVID-19 病例接触与可检测到的 IgG 相关（12.8%对 4.4%，p=0.02），但与 COVID-19 患者接触无关。
在大型医疗保健系统中的 HCP 中，有 6.1%可检测到 SARS-CoV-2 IgG。血清阳性与医疗环境外的暴露有关。
