Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Georgia Emerging Infections Program, Decatur, Georgia.
Infect Control Hosp Epidemiol. 2022 Nov;43(11):1664-1671. doi: 10.1017/ice.2021.518. Epub 2022 Feb 14.
To determine the incidence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare personnel (HCP) and to assess occupational risks for SARS-CoV-2 infection.
Prospective cohort of healthcare personnel (HCP) followed for 6 months from May through December 2020.
Large academic healthcare system including 4 hospitals and affiliated clinics in Atlanta, Georgia.
HCP, including those with and without direct patient-care activities, working during the coronavirus disease 2019 (COVID-19) pandemic.
Incident SARS-CoV-2 infections were determined through serologic testing for SARS-CoV-2 IgG at enrollment, at 3 months, and at 6 months. HCP completed monthly surveys regarding occupational activities. Multivariable logistic regression was used to identify occupational factors that increased the risk of SARS-CoV-2 infection.
Of the 304 evaluable HCP that were seronegative at enrollment, 26 (9%) seroconverted for SARS-CoV-2 IgG by 6 months. Overall, 219 participants (73%) self-identified as White race, 119 (40%) were nurses, and 121 (40%) worked on inpatient medical-surgical floors. In a multivariable analysis, HCP who identified as Black race were more likely to seroconvert than HCP who identified as White (odds ratio, 4.5; 95% confidence interval, 1.3-14.2). Increased risk for SARS-CoV-2 infection was not identified for any occupational activity, including spending >50% of a typical shift at a patient's bedside, working in a COVID-19 unit, or performing or being present for aerosol-generating procedures (AGPs).
In our study cohort of HCP working in an academic healthcare system, <10% had evidence of SARS-CoV-2 infection over 6 months. No specific occupational activities were identified as increasing risk for SARS-CoV-2 infection.
确定医护人员（HCP）中严重急性呼吸冠状病毒病毒 2（SARS-CoV-2）感染的发生率，并评估 SARS-CoV-2 感染的职业风险。
对 2020 年 5 月至 12 月期间进行了 6 个月随访的医护人员（HCP）进行前瞻性队列研究。
包括佐治亚州亚特兰大的 4 家医院和附属诊所在内的大型学术医疗保健系统。
包括有和没有直接患者护理活动的医护人员，在 2019 年冠状病毒病（COVID-19）大流行期间工作。
通过在入组时、3 个月时和 6 个月时进行 SARS-CoV-2 IgG 的血清学检测来确定 SARS-CoV-2 感染的情况。HCP 每月完成一次关于职业活动的调查。采用多变量逻辑回归来确定增加 SARS-CoV-2 感染风险的职业因素。
在 304 名可评估的入组时血清学阴性的 HCP 中，有 26 名（9%）在 6 个月时 SARS-CoV-2 IgG 血清转化。总体而言，219 名参与者（73%）自我认定为白人种族，119 名（40%）为护士，121 名（40%）在住院内科外科病房工作。在多变量分析中，黑人种族的 HCP 比白人种族的 HCP 更有可能血清转化（优势比，4.5；95%置信区间，1.3-14.2）。没有发现任何职业活动（包括在患者床边度过超过典型班次的 50%、在 COVID-19 病房工作或进行或在场进行气溶胶生成程序（AGPs））会增加 SARS-CoV-2 感染的风险。
在我们的学术医疗保健系统中工作的医护人员研究队列中，不到 10%的人在 6 个月内有 SARS-CoV-2 感染的证据。没有发现任何特定的职业活动会增加 SARS-CoV-2 感染的风险。
