Wang Guangxia
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, CAS, Shanghai, 200031, China.
Biochem Biophys Res Commun. 2022 Jun 25;610:23-29. doi: 10.1016/j.bbrc.2022.04.025. Epub 2022 Apr 8.
Motivational states are important determinants of behavior. In Drosophila melanogaster, courtship behavior is robust and crucial for species continuation. However, the motivation of courtship behavior remains unexplored. We first find the phenomenon that courtship behavior is modulated by motivational state. A male fly courts another male fly when it first courts a decapitated female fly, however, male-male courtship behavior rarely occurs under normal conditions. Therefore, in this phenomenon, the male fly's courtship motivational state is induced by its exposure to female flies. Blocking dopaminergic neurons synaptic transmission by expressing Tetanus toxin light chain (TNTe) decreases motivational state induced male-male courtship behavior without affecting male-female courtship behavior. Vision cues are another key component in sexually driven Drosophila male-male courtship behavior. Here, we identify a base theory that the inner motivational state could eventually decide Drosophila behavior.
动机状态是行为的重要决定因素。在黑腹果蝇中，求偶行为强烈且对物种延续至关重要。然而，求偶行为的动机仍未得到探索。我们首先发现求偶行为受动机状态调节这一现象。当一只雄蝇首次向一只断头雌蝇求偶时，它会向另一只雄蝇求偶，然而，在正常情况下雄雄求偶行为很少发生。因此，在这种现象中，雄蝇的求偶动机状态是由其接触雌蝇所诱导的。通过表达破伤风毒素轻链（TNTe）阻断多巴胺能神经元的突触传递，可降低动机状态诱导的雄雄求偶行为，而不影响雌雄求偶行为。视觉线索是性驱动的果蝇雄雄求偶行为中的另一个关键组成部分。在此，我们确定了一个基本理论，即内在动机状态最终可以决定果蝇的行为。
