Salem A M, Adams D, Newman H N, Rawle L W
J Clin Periodontol. 1987 Jan;14(1):44-7. doi: 10.1111/j.1600-051x.1987.tb01512.x.
The surfactants tetradecylamine, hexadecylamine and chlorhexidine have been compared with regard to their ability to inhibit microbial growth. Antibacterial activity was assessed by tube dilution methods. Tetradecylamine and chlorhexidine were similar in antibacterial activity, being effective at low concentrations against most organisms tested. Hexadecylamine also inhibited growth but at higher concentrations. Viable counts of salivary organisms were monitored in volunteers over 48 h after one rinse with the agents. The initial reduction in numbers of total viable salivary bacteria and streptococci by tetradecylamine and of streptococci by hexadecylamine had disappeared 3 h after a single mouth rinse, but the reduction in numbers of all salivary bacteria by chlorhexidine was more prolonged.
已对表面活性剂十四烷基胺、十六烷基胺和洗必泰抑制微生物生长的能力进行了比较。通过试管稀释法评估抗菌活性。十四烷基胺和洗必泰的抗菌活性相似，在低浓度下对大多数测试微生物有效。十六烷基胺也能抑制生长，但需要更高的浓度。在用这些试剂单次漱口后，对志愿者48小时内唾液微生物的活菌计数进行了监测。单次漱口3小时后，十四烷基胺使唾液中总活菌数和链球菌数量最初减少的情况以及十六烷基胺使链球菌数量减少的情况消失，但洗必泰使所有唾液细菌数量减少的情况持续时间更长。
